摘要
白念珠菌是常见机会致病菌，耐药率呈逐年上升趋势，其抗真菌药物的种类亦较多。白念珠菌的耐药机制具有多样性，例如，麦角甾醇生物合成的改变、药物外排增强、细胞膜中磷脂和固醇组成比例的改变、细胞壁葡聚糖的改变、细胞核DNA合成的改变及生物膜的形成等。白念珠菌耐药株中耐药机制的形成并非单机制，而是多种耐药机制相互协作的产物，应积极防控。
Various antifungal agents have been used in the treatment of Candida albicans infection. As a common opportunistic pathogen, Candida albicans has shown an increasing antifungal resistance year by year, which are believed to result from the collaborative interaction between multiple complex mechanisms, including changes in ergosterol biosynthesis, enhancement of drug efflux, alterations in the molar ratio of phospholipid to sterol in cell membrane, glucan in cell wall and in DNA synthesis in cell nuclei, as well as biofilm formation. Active measures should be taken to prevent and control Candida albicans infection.
出处
《国际皮肤性病学杂志》
2013年第1期66-68,共3页
International Journal of Dermatology and Venereology
基金
基金项目：卫生部艾滋病防治应用性研究项目（WA-2006-08）
新疆医科大学研究生创新基金（MC2010-15）
关键词
念珠菌
白色
抗真菌药
抗药性
Candida albieans
Antifungal agents
Drug resistance
