摘要
免疫学是一门理论探索性强、实际应用性大的生物医学领域前沿性支柱性学科,是连接基础医学与临床医学的桥梁学科,也被誉为转化医学的核心学科.近年的研究表明,以往以血液和骨髓为主体的免疫学研究数据与肠、肺、泌尿系统等称为黏膜免疫系统组织器官的免疫学特性存在巨大区别,更与尚未列为免疫器官而又独具免疫特性的器官/组织(如肝、胰、骨、子宫、肾等)的特性相差甚远.这些"非专职"的免疫器官/组织由于具有独特的结构和微环境,含有独特的免疫细胞亚群和功能分子,构成了独特的区域免疫学特性,并与所在区域的器官/组织的众多疾病的发生发展紧密相关.目前,多数"非免疫"组织器官的区域免疫特性及其疾病机理、"专职免疫"器官与"非免疫"器官间的区域免疫特性的关系以及循环免疫系统对主要组织器官的区域免疫特性形成的关系均缺乏系统研究.对这些组织器官的区域免疫学特性、细胞分子调控网络进行基础性、前沿性的先导研究,将揭示区域免疫反应与重大疾病的内在联系,有助于寻找新的免疫治疗靶点.这既是免疫学研究的前沿领域,又符合国家的重大需求.
Immunology is a pioneer and practical discipline in biomedical science,bridging basic biologic knowledge with clinical medicine,so called core of translational medicine.Recently,it was noted that the immunologic parameters from blood and bone marrow greatly differ in those not only from mucosal immune system including gastrointestinal tract,respiratory tract and urogenital tract but also from the non-immune organs such as liver,pancreas,bone,uterine,kidney,and so on.These mucosal immunologic and ＂unprofessional immune＂ tissue/organs are characterized with their own anatomy,microenvironment,immune cell population and subsets with unique functional molecules,forming unique regional immune features which dominantly control the disease process related to each tissue/organ.At present,there are few studies to explore the relationship of ＂unprofessional immune＂ tissue/organs to disease mechanisms,to professional immune tissue/organs,to circulating immune system.The frontier research on tissue/organ-specialized immune features and their molecular and cellular mechanisms will greatly improve to deep elucidate the relation of regional immunity to major diseases and to extensively discover novel immunotherapeutic targets.So,tissue/organ-specialized immunology is leading the immunologic study and is in keep with national requirement.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2012年第36期3450-3458,共9页
Chinese Science Bulletin
关键词
免疫学
组织器官的区域
免疫特性
疾病机理
immunology
tissue/organ-specialized regional immunologic features
disease mechanisms
