摘要
目的 通过对非小细胞肺癌(NSCLC)患者的焦虑和抑郁水平和免疫功能的研究,探索该病患者的抑郁情况与免疫功能之间的关系.方法 选2014年11月至2018年10月在山西医科大学第二医院被确诊为NSCLC的152例患者,使用Zung焦虑自评量表(SAS)和抑郁自评量表(SDS)进行焦虑和抑郁水平测试,采用静脉采血进行免疫功能测试;使用单因素方差分析确定抑郁与免疫功能的相关关系,使用Logstic回归分析确定影响患者抑郁的风险因素.结果 ①焦虑发生率为31.6%,抑郁发生率38.8%.②单因素方差分析显示,肺癌抑郁患者CD4+/CD8+低于无抑郁肺癌患者;③单因素方差分析显示,与无抑郁NSCLC患者相比,抑郁患者未婚/丧偶比例更大,肺癌分期更严重,卡式评分(KPS)评分更低;④Logstic回归分析显示,肺癌患者KPS评分是患者抑郁的风险因素.结论 婚姻状态、肺癌分期、KPS评分是NSCLC患者是否抑郁的影响因素,其中KPS是患者抑郁水平的风险因素;抑郁的NSCLC患者的免疫功能低于无抑郁NSCLC患者.
Objective To determine the anxiety and depression levels and immune function in patients with non-small cell lung carcinoma(NSCLC),and to investigate the relationship between depression and immune function.Methods A total of 152 patients,who were diagnosed with NSCLC in our hospital between November 2014 and October 2018,were included in the study.Zung′s self-rating anxiety scale(SAS)and self-rating depression scale(SDS)were used to examine the anxiety and depression levels.Intravenous blood sampling was used for immune function testing.One-way analysis of variance(ANOVA)was used to determine the relationship between depression and immune function.Logistic regression analysis was used to determine the risk factors for depression in patients.Results The incidence of anxiety and depression was 31.6%and 38.8%,respectively.One-way ANOVA showed that the CD4+/CD8+level in NSCLC patients with depression was lower than that in patients without depression.According to one-way ANOVA,greater unmarried/widowed proportion,more severe stage of lung cancer,and lower Karnofsky performance status(KPS)score were found in NSCLC patients with depression compared with those without depression.Logistic regression analysis showed that the KPS score was a risk factor for depression in NSCLC patients.Conclusion Marital status,lung cancer stage and KPS score are the influencing factors of depression in NSCLC patients,and KPS score is a risk factor of depression.The immune function in NSCLC patients with depression is lower than that in NSCLC patients without depression.
作者
王加瑛
刘晓菲
任燕
Wang Jiaying;Liu Xiaofei;Ren Yan(Department of Respiratory Medicine,Gastroenterology and Oncology,West Division,Second Hospital of Shanxi Medical University,Taiyuan030001,China)
出处
《中国药物与临床》
CAS
2020年第16期2661-2664,共4页
Chinese Remedies & Clinics
基金
山西省留学人员科技活动择优资助项目(晋财社〔2019〕91号)。
关键词
癌
非小细胞肺
抑郁
焦虑
免疫
T淋巴细胞亚群
杀伤细胞
天然
Carcinoma
non-small cell lung carcinoma
Depression
Anxiety
Immunity
T lymphocyte subsets
Killer cells
natural
