摘要
目的探讨在西部欠发达地区应用青霉素联合氯霉素治疗小儿化脓性脑膜炎的疗效及可行性。方法将确诊为小儿化脓性脑膜炎的132例患儿随机分为对照组和治疗组各66例,对照组使用常规青霉素治疗,治疗组在对照组的基础上联合应用氯霉素,观察2组患儿治疗后的效果。结果治疗组与对照组相比,治疗组体温恢复正常时间、外周白细胞计数恢复正常时间及脑脊液白细胞计数恢复正常时间较对照组明显缩短,差异均有统计学意义(P<0.05)。结论青霉素联合氯霉素治疗儿童化脓性脑膜炎疗效显著、经济安全。
Objective To discuss the efficacy and feasibility of combination therapy of penicillin and chloramphenicol for pediatric suppurative meningitis in less-developed areas.Methods The 132 patients diagnosed as purulent meningitis were randomly divided into control group and treatment group,each of 66 cases.Only penicillin was used in the control group,and the chloramphenicol was applied in combination with penicillin in the treatment group.The effects of the 2 groups were observed after treatment.Results Compared with the control group,the recovery time of temperature,peripheral white blood cell count and cerebrospinal fluid white blood cell count in the treatment group is shorter obviously,and the differences were statistically significant （P0.05）.Conclusion The combination therapy method of penicillin and chloramphenicol for pediatric suppurative meningitis is effective,economical and safe.
出处
《临床合理用药杂志》
2012年第35期33-34,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
化脓性脑膜炎
青霉素
氯霉素
Suppurative meningitis
Penicillin
Chloramphenicol
