摘要
目的了解视神经脊髓炎（NMO）患者的认知障碍特点。方法收集12例NMO患者、15例多发性硬化（MS）患者和15例正常人依次作为NMO组、MS组和正常组，评估各组受试者的工作记忆及信息处理速度、词语记忆能力、语义流畅度、视空间结构及视空间记忆能力、执行功能共5个领域的认知功能，分别采用中文听觉连续加法测试3／2S版（PASA33／2）、听觉词语记忆测试（CRAVLT）、词语流畅性测试（VFT）、Rey复杂图形记忆测试（RCFT）、Stroop字-色干扰试验（Stroop）进行评估。评估NMO和MS组患者的临床症状，采用扩展残疾状况评分量表（EDSS）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、疲劳严重程度量表（FSS）、匹兹堡睡眠质量指数（PSQI）进行评估。各项量表的得分经方差分析等统计学处理。结果NMO组、MS组、正常组中的PASAT3得分[分别为（33．3±9．6）分、（38．9±14．3）分、（45．5±8．6）分]，VFT得分[分别为（24．8±8．7）分、（26．4±8．4）分、（31．7±4．7）分]，差异有统计学意义（P〈0．05），其他认知测验差异无统计学意义（P〉0．05）。结论NMO患者的工作记忆及信息处理速度、语义流畅度存在障碍，而词语记忆能力、执行能力、视觉空间结构和视觉记忆能力基本保留，与MS患者的认知障碍特点不全相同。
Objective To investigate the characteristics of cognitive impairment in neuromyelitis optica （NMO） patients. Methods 12 NMO patients, 15 multiple sclerosis （MS） patients and 15 healthy people were collected and grouped as NMO group, MS group and normal control group. The five cognitive domains including working memory and information processing speed, verbal memory ability, semantic fluency, visual spatial structure and visuospatial recall ability, and executive function were evaluated respectively by the five tests,which are the 3/ 2 second edition of Chinese Version Auditory Continuous Addition test （ PASAT3/2）, the Chinese Rey Auditory Verbal Learning test （CRAVLT） ,Verbal Fluency test （VFT） ,the Rey Complex Figure test （RCFT） and the Chinese Version of the Stroop Colour-Word test （Stroop）. The severity of somatic dysfunction and disability, depression, anxiety, fatigue and the sleep quality were evaluated both in NMO and MS patients by the Expanded Disability Status Scale Rating Scale （ EDSS）, Hamilton Depression Rating Scale （ HAMD ）, Hamilton Anxiety Scale （ HA- MA）, Fatigue Severity Scale （FSS） and the Pittsburgh Sleep Quality Index （PSQI）. Analysis of variance, Mann- Whitney and Kruskal-Wallis H test were performed to determine significant differences among three groups. Results The PASAT3 accomplishments were （ 33.3 ± 9.6）, （ 38.9 ± 14.3 ）, （45.5 ± 8.6） respectively, the VFT scores were （ 24.8 ± 8.7 ）, （ 26.4 ± 8.4）, （ 31.7 ± 4.7 ） respectively in NMO group, MS group and control group, and the differences of PASAT3 and VFT among three groups were significant （P 〈 0.05 ）. However, PASAT2, CRAVLT （N1-5, N6,7,8,9） ,RCFT and Stroop test scores were not significant differenence （P 〉 0.05 ）. Conclusion NMO patients exist obstacle in working memory and information processing speed, semantic fluency, but still retain other aspects of the verbal memory capacity, executive function, visual-spatial structures and visual me
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2012年第12期1098-1100,共3页
Chinese Journal of Behavioral Medicine and Brain Science
关键词
视神经脊髓炎
认知障碍
多发性硬化
Neuromyelitis optica
Cognitive impairment
Multiple sclerosis
