摘要
目的:研究盐酸多奈哌齐改善精神分裂症认知功能的效果。方法:将50例未服过抗精神病药的精神分裂症患者,随机分为利培酮(4mg/d)联合盐酸多奈哌齐组(5~10mg/d)(研究组,23例)和利培酮(4mg/d)联合安慰剂组(对照组,24例),治疗12周。于治疗前和治疗6周末及12周末测定认知功能,用阳性和阴性症状量表(PANSS)于治疗前和治疗12周末评定临床疗效。结果:治疗12周末,两组各认知测验和PANSS分较治疗前均有改善,差异有统计学意义(P<0.05或P<0.01);数字广度测验、视觉再生测验和连线A测验总分变化值研究组高于对照组(P<0.05或P<0.01)。结论:盐酸多奈哌齐可以改善精神分裂症的记忆功能,建议大样本的研究进一步证实。
Objective:To evaluate the effects of donepezil on cognitive impairments in patients with schizophrenia.Method:We conducted a 12-week,double-blind,placebo-controlled trial of donepezil as adjunctive treatment to risperidone on 50 patients with schizophrenia.The study group was given with risperidone(4 mg/d) and donepezil(5~10 mg/d),and the control group was given with risperidone(4 mg/d) and placebo during 12 weeks treatment period.Results:The scores of all cognitive measures and PANSS in endpoint were significantly reduced compared with baseline in both groups(P0.05).However,the study group demonstrated greater improvement in the visual reproduction test,trail making tests part A and digit span than did the control group(P0.05 or P0.01).Conclusion:Donepezil as adjunctive therapy may improve memory function of patients with schizophrenia,and future studies require large sample sizes to achieve sufficient power.
出处
《临床精神医学杂志》
2011年第4期249-251,共3页
Journal of Clinical Psychiatry