摘要
研究SOD活性在正常成人与消化性溃疡、胃癌患者血浆和胃黏膜病变组织中的变化。用改良邻苯三酚自氧化法测定正常人与消化性溃疡和胃癌患者血浆、组织中超氧化物歧化酶(SOD)活性。结果显示,溃疡患者血浆SOD活性为3.555U/μl,与正常人相比(P>0.05);组织中SOD活性为1.502U/μl,低于正常人(P<0.001);胃癌患者血浆中SOD活性为3.081U/μl,组织中SOD活性为0.55U/μl,均低于正常对照与溃疡病患者(P<0.001)。溃疡、癌症时组织中SOD活性均降低,后者明显低于前者。SOD活性测定有可能成为胃癌诊断中一个敏感的有价值的临床生化检验指标。
Study normal subjects and peptic ulcer, gastric cancer patients in plasma and gastric mucosa lesion tissue SOD ac tivity change. With the improved adjacent benzene three phenolic autoxidation method to determine superoxide dismutase （SOD） activity in, tissue of the normal, peptic ulcer and gastric cancer patients. The results showed, Ulcer patient plasma SOD activity for 3. 555U/μl, Compared with normal （P〉0.05）; Organization SOD activity of 1. 502 U/μl, lower than normal （P〈0. 001 ） ; gastric cancer patients in plasma SOD activity of 3. 081 U/μl, tissue SOD activity of 0.55 U/μl, were low er than those of normal controls and patients with ulcers （P〈0. 001 ）. Ulcer, cancer SOD activity was reduced, which the latter obviously lower than the former. The determination of SOD activity in diagnosis of gastric cancer may be a sensitive and valuable clinical biochemical indexes.
出处
《医学与哲学（B）》
2012年第12期42-43,共2页
Medicine & Philosophy(B)
基金
内蒙古自治区高等学校科学技术研究项目
项目编号:NJZY12221
关键词
超氧化物歧化酶
消化性溃疡
胃癌
superoxide dismutase （ SOD）, peptic ulcer, gastric cancer
