摘要
目的通过对３９例老年高血压患者超氧化物歧化酶（ＳＯＤ）活性及血清一氧化氮（ＮＯ）含量的测定，进一步了解高血压与ＮＯ及氧自由基的关系。方法对３９例老年高血压患者，男２４例，女１５例，用比色法测定其ＮＯ含量，用邻苯三酚自氧化法测定ＳＯＤ活性。结果正常对照组ＮＯ含量为７８．１±２２．９μｍｏｌ／Ｌ，ＳＯＤ活性为２７６．４±５７．３Ｕ／Ｌ，老年高血压组ＮＯ含量为５１．８±２０．７μｍｏｌ／Ｌ，ＳＯＤ活性为１６７．４±５２．８Ｕ／Ｌ。高血压组与正常对照组相比，血清ＮＯ含量显著下降（Ｐ＜０．０１），ＳＯＤ活性显著下降（Ｐ＜０．０１），且随病情的加重而下降。结论提示ＮＯ对高血压有防护作用，而ＳＯＤ能增强ＮＯ的防护作用。
Objective To survey the changes in serum nitric oxide (NO) and superoxide dismutase (SOD)in aged hypertensives. Methods In 39 hypertensive patients (average age 70 2±8 1 years,24 male and 15 female),the serum nitrite and superoxide dismutase were determined by colorimeteric method and by the method of autoxidation of pyrogallol,respectively. Results The level of serum NO was 78 1±22 9 μmol/L and SOD 276 4±57 3U/L in the controls;the level of serun NO was 51 8±20 7μmol/L and SOD 167 4±52 8U/L in the aged hypertensives.The level of serum nitrite and superoxide dismatase were significantly lower in the aged hypertensives than in the controls ( P <0 01).The changes were correlated with the degree of the severity of hypertension. Conclusions Nitric oxide may be a protective factor against hypertension and SOD can enhence the protective role of nitric oxide.
出处
《实用老年医学》
CAS
1998年第5期221-222,共2页
Practical Geriatrics
