摘要
小泛素相关修饰物(small ubiquitin-related modifier,SUMO)是一种与泛素类似的小分子蛋白,其共价结合到靶蛋白赖氨酸残基上的修饰过程称为SUMO化。SUMO化具有广泛的生物学功能,它可通过修饰转化生长因子-β信号通路中的某些重要信号分子来对该通路进行调控。
The small ubiquitin-related modifier （SUMO） is a small ubiquitin-like molecule. It can covalently attach to lysine residues of target proteins. This process is referred to SUMOylation, which has a wide range of biological functions. SUMO can regulate the transforming growth factor-β （TGF-β） pathway by modifying some important signaling molecules through SUMOylation.
出处
《国际病理科学与临床杂志》
CAS
2012年第6期541-545,共5页
Journal of International Pathology and Clinical Medicine
关键词
小泛素相关修饰物
转化生长因子-Β
信号通路
small ubiquitin-related modifier
transforming growth factor-β
signal pathway
