摘要
Galectin-3是半乳糖凝集素家族中的一员,能通过其糖识别域与细胞内糖蛋白、细胞表面分子和细胞外基质蛋白相互作用,参与胚胎着床、胚胎发生和胎盘形成等过程,与妊娠成功建立和维持密切相关。凋亡抑制蛋白Bcl-2与Galectin-3有明显的序列相似性,可能存在共同细胞凋亡通路,在人早孕过程中参与了绒毛滋养层细胞的增殖和分化、子宫内膜蜕膜化的过程,在绒毛的发生、发育、胎盘形成和组织结构改建及功能完善等方面发挥着重要作用。
Galectin-3 is a member of galectin family,which interacts with intracellular glycoprotein,cell surface molecules and extracellular matrix proteins by its carbohydrate recognition domains,participates the progress of embryo implantation,embryogenesis and placenta formation,and establishes and maintains a close relationship with pregnancy.Inhibitors of apoptosis protein Bcl-2 and Galectin-3 have significant sequence similarity,and may have the same apoptosis pathway,which participates in the growth and differentiation of villous trophoblast cells in people′s earlier pregnancy and the process of decidualization of endometrium,in addition,playing a critical role in the villous production,growth,placenta formation and in its tissue structure rebuilding and functional perfection.
出处
《医学综述》
2012年第24期4147-4149,共3页
Medical Recapitulate
