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地佐辛超前应用预防瑞芬太尼复合麻醉患者苏醒期躁动的观察 被引量:10

Preemptive Analgesia Effect and Safety of Dezocine for Postoperative Agitation Patients after Remifentanil-Based Anesthesia
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摘要 目的评价探讨地佐辛超前应用预防瑞芬太尼复合全麻下患者术后躁动的有效性与安全性。方法择期行妇科腹腔镜手术患者80例,随机分为地佐辛组(A组)和对照组(B组)。持续静脉输注丙泊酚和瑞芬太尼并间断静脉注射顺阿曲库铵维持麻醉。A组诱导前静脉注射地佐辛0.05mg/kg。观察两组患者苏醒期的躁动情况,记录苏醒时间、拔除气管导管时间,记录拔管后即刻(T1)、拔管后30min(T2)时MAP、HR、SpO2、视觉模拟评分(VAS)和Ramsay评分,记录拔除气管导管后呼吸抑制、恶心呕吐的发生情况。结果 A组苏醒期躁动发生率和躁动程度、MAP、HR、VAS评分和恶心呕吐发生率低于B组(P<0.05);A组Ramsay评分高于B组(P<0.01);两组苏醒时间和拔管时间、SpO2和呼吸抑制发生率差异无统计学意义(P>0.05)。结论诱导前静脉注射地佐辛0.05mg/kg能安全有效地预防瑞芬太尼复合全麻患者苏醒期躁动的发生。 Objective To evaluate the preemptive analgesia efficacy and safety of dezocine on postoperative agitation patients after remifentanil- based anesthesia. Methods Eighty patients undergoing gynecological laparoscopic surgery were randomly divided into two groups: dezocine group (group A) and control group (group B), using continuous intravenousion of propofol-remifentanil, given intermittent cisatracurium to maintain anesthesia. Group A were given 0.05 mg/kg of dezocine before induction, to investigate emergence agitation of two the groups, and to record MAP, HR, SpO2, The scores of VAS and Ramsay at the time of recovery and just after extubation (T1), 30 min (T2) after extubation and the incidence nausea and vomiting were recorded as well. Results Compared with group B, the incidence and the level of emergence agitation, MAP, HR, the scores of VAS and the rate of nausea and vomiting were lower (P 〈0.05); The score of Ramsay Group A got higher scores in Ramsay (P 〈0.01). There were no significantly difference of the time of recovery, extubation, the incidence of SpO2 and respiratory depression (P 〉0.05). Conclusions 0.05 mg/kg of dezocine given before induction can prevent emergence agitation effectively and safely after remifentanil-based anesthesia.
作者 李岱 林启勇
出处 《临床医学工程》 2012年第12期2182-2183,共2页 Clinical Medicine & Engineering
关键词 地佐辛 瑞芬太尼 苏醒期躁动 痛觉过敏 Dezocine Remifentenil Emergence agitation Hyperalgesia
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