摘要
本文主要研究当归补血汤(DBT)对环磷酰胺(Cy)所致家兔血细胞减少的影响。将40只新西兰白兔(1.7～1.9kg)随机分为4组,Ⅰ、Ⅱ、Ⅲ组按75mg/kg体重腹腔注射环磷酰胺(Cy),连续3d,诱发家兔血细胞减少。Ⅰ、Ⅱ组分别给予1mL/kg的当归补血汤和玉屏风口服液(YPF),Ⅲ组为环磷酰胺对照,Ⅳ组等剂量注射生理盐水作为健康空白对照。试验期15d,观察药物对免疫抑制家兔血液学指标如白细胞计数(WBC)、红细胞计数(RBC)、平均血红蛋白含量(HGB)、血小板计数(PLT),以及体重的影响。结果显示:YPF和DBT对Cy造模家兔的血液学指标有一定程度的恢复作用,且DBT效果优于YPF,但均未能使WBC、RBC、HGB、PLT值达到正常水平;YPF和DBT对Cy造模家兔的体重增长无明显影响。本试验证明:"当归补血汤"能改善环磷酰胺所致血细胞减少家兔的血液学指标,效果优于临床常用的经典方剂"玉屏风",但尚不能恢复到正常水平。
A total of 40 female rabbits （initial body weight： 1.7-1.9kg） were randomly distributed to 4 groups. Beginning the first day and ending the fourth day, rabbits in group Ⅰ , Ⅱ and Ⅲ were injected daily in the abdominal region with a dosage of 75 mg/kg cyclophosphamide. At the same time, rabbits in group Ⅳ were injected with isodose normal saline. Then, rabbits in group Ⅰ and Ⅱ were received a dose of 1 mL/kg DBT or YPF respectively. WBC, RBC, r HGB, and PLT in group Ⅰ and Ⅱ were significantly enhanced than those of group Ⅲ. However, the hematology status of rabbits in group Ⅰ and Ⅱ were not recuperated to normal level. Our results suggested that DBT can ameliorate hypocytosis status that induced by cyclophosphamide in rabbits.
出处
《四川畜牧兽医》
2012年第12期19-20,23,共3页
Sichuan Animal & Veterinary Sciences
基金
四川省良种繁育专项基金(SASA2012YZ001)
