摘要
目的评价加用丙氨酰谷氨酰胺注射液的肠外营养对胃肠癌患者术后营养状态及免疫功能的影响。方法将84例胃肠癌患者随机分为对照组与试验组,每组42例,所有患者均于术后第1～7 d给予等热量(98.0 kJ·kg-1·d-1)、等氮(0.25 g·kg-1·d-1)的肠外营养治疗,试验组加用丙氨酰谷氨酰胺注射液0.5 g·kg-1·d-1。观察患者术前,术后2,7 d的血清白蛋白、血清前蛋白、各细胞及体液免疫指标及氮平衡变化,并进行比较分析。结果 2组患者血清白蛋白、前白蛋白在术后第2 d均有下降,与术前相比差异有统计学意义(P<0.01);术后第7 d时,均有回升,但对照组回升较慢,2组比较差异有统计学意义(P<0.05)。患者术后的各项细胞免疫指标及体液免疫指标都出现下降,术后第7 d,对照组的IgG仍显著低于术前(P<0.05),其他均基本恢复到术前,试验组的IgA、IgG显著高于对照组(P<0.05)。氮平衡,术后第7 d试验组明显优于对照组(P<0.01)。结论胃肠癌患者术后肠外营养治疗基础上联合加用丙氨酰谷氨酰胺注射液更能有效改善机体营养和免疫状况,从而促进预后。
Objective To investigate the effects of alanyl glutamine par- enteral nutrition injection on nutritional status and immune function in gastrointestinal cancer patients. Methods A total of 84 cases of gastroin- testinal cancer patients were randomly divided into control group and experimental group and each group included 42 cases. After surgery all patients were given parenteral nutrition therapy with same calorie （98.0 kJ. kg-1 . d-1） and nitrogen （0.25 g. kg-1 . d-1） for 1 -7 days. The patients in the experimental group were additionally used the alanyl -glutamine injection 0. 5 g . kg-1 . d-1. The serum albumin, serum precursor protein, the cells and humoral immunity and nitrogen balance changes before operation and after operation 2 days and 7 days were ob- served and analyzed. Results Two groups of patients with serum albu- min, prealbumin on second postoperative day were significantly decreased compared with preoperative data （ P 〈 0.01 ）. On the 7th postoperative day the serum albumin and prealbumin in both groups were raised, but the control group rebounded slower than experimental group （ P 〈 0.05 ）. The cellular immune indicators and humoral immunity of patients had value of IgG in control group in the 7th postoperative day ,（P〈0. 05 ）, and the other indicatorswere recovered to the preoperative. The values of IgA and IgG in the experimental group were significantly higher than the control group （ P 〈 0.05 ）. The nitrogen balance of the experimental group was better than the control group after op- eration 7 days （P 〈0. 01 ）. Conclusion Parenteral nutrition therapy plusing alanyl - glutamine injection can be effec- tive in improving the body＇s nutritional and immune status, thus contributing to the prognosis of patients with gastroin- testinal cancer.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2012年第12期947-949,共3页
The Chinese Journal of Clinical Pharmacology
关键词
丙氨酰谷氨酰胺
肠外营养
胃肠癌
营养状况及免疫功能
alanyl - glutamine
parenteral nutrition
gastrointestinal cancer
nutritional status and immune function
