摘要
目的观察丙氨酰-谷氨酰胺对全合一肠外营养液稳定性尤其是脂肪乳剂稳定性的影响。方法将丙氨酰-谷氨酰胺分别加入3种不同配方的全合一肠外营养液中,在不同温度下、24小时内取样观察外观变化,测定pH值、渗透压值。观察脂肪乳剂在加入丙氨酰-谷氨酰胺后颗粒大小及形态有无改变并计算平均粒径。结果不同配方全合一肠外营养液加入丙氨酰-谷氨酰胺后,其外观、pH值、渗透压值未见明显改变,脂肪乳剂颗粒大小及形态亦无明显变化。临床应用100人次,未见不良反应。结论丙氨酰-谷氨酰胺可加入全合一肠外营养液中进行配伍使用。
Objective To evaluate the stability of total parenteral nutrition （ TPN ）, especially the fat emulsion, when added with alany-glutamine. Methods The appearance was observed under various temperatures. The pH and osmotic pressure were measured when alany-glutamine was added into three different TPN prescriptions. The diameter and surface looking for fat emulsion particles were measured. Results There were not obvious changes in appearance, pH and osmotic pressure. The size and surface of fat emulsion particles were stable when TPN was mixed with alany-glutamine. No side effect was reported when such TPN was used in 100 person-times in clinical practice. Conclusion Totle parenteral nutrition prescription is stable after being added with alany-glutamine.
出处
《中国临床营养杂志》
2006年第3期163-166,共4页
Chinese Journal of Clinical Nutrition
