摘要
目的 :评价宫颈癌新辅助化疗的临床和组织学疗效。方法 :对 3 1例肿块直径≥ 4cm的 IB- B 期宫颈癌患者给予以顺铂为基础的新辅助化疗和手术治疗 ,观察其临床疗效 ,并对其中 2 8例化疗后组织学变化进行分析。结果 :3 1例化疗后临床完全缓解 7例 ,部分缓解 1 4例 ,总有效率为67.7% (2 1 / 3 1 ) ;盆腔淋巴结转移 1 0例 ,转移率 3 2 .3 % (1 0 / 3 1 )。组织学观察发现 ,2 8例患者化疗后宫颈癌原发灶内组织学变化达 、 者 1 3例 ,组织学有效率 46.4%。盆腔淋巴结转移灶内组织学变化达 、 者 5例 ,组织学有效率 5 0 .0 %。化疗后宫颈癌患者原发灶内癌周纤维结缔组织增生与化疗前相比有非常显著的差异 (P<0 .0 0 5 ) ,癌周间质细胞反应与化疗前相比也有显著差异 (P<0 .0 5 )。结论 :新辅助化疗近期临床疗效良好 ,对宫颈癌原发灶和转移灶均有一定的组织学疗效。
Objective:To evaluate the clinical and histological response of the neoadjuvant chemothe rapy (NACT) for the patients with cervical cancer.Methods:NACT was given to patents with Ⅰ B Ⅱ B cervical cancer.Clinical effects and histologic changes were simultaneously recorded.Results:At the end of NACT,the complete response,partical response were occurred in 7 and 14 patients,respectively.The overall response rate was 67.7%(21/31).Pelvic lymph node metastases were found in 10 patients(32.3%).In primary lesions the histological response was considered as grade Ⅱ or Ⅲ in 13 cases after NACT,the rate of histological response was 46.4%.And in lymph node metastases,grade Ⅱ or Ⅲ was found in 5 patients,the rate of histological response was 50.0%.In primary lesions,peritumoral fibrous tissue reaction was obviously significant after NACT( P <0.005),and stroma lymphocytic infiltration was increased significantly after NACT( P <0.05).Conclusion:NACT has a good clinical effect and some histological effects against primary and metastases lesions of cervical cancer.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2000年第3期111-113,共3页
Journal of Zhejiang University(Medical Sciences)
关键词
抗肿瘤药
药物疗法
宫颈肿瘤
病理学
辅助疗法
Antineoplastic agents,combined
Cervix neoplasms/drug ther
Cervix neoplasms/surg
Cervix neoplasms/pathol
