摘要
目的:比较3种用药途径对宫颈癌术前辅助化疗的疗效及不良反应。方法:我院1996-2010年期间收住巨块型宫颈癌Ⅰb2～Ⅱb期患者1175例,术前均辅助化疗。观察化疗后的肿瘤缓解情况、肿瘤缩小率及不良反应、并发症、术中出血以及手术切除率。结果:腹壁下动脉插管灌注组行手术256例,介入组352例,静脉化疗组287例;腹壁下动脉组及介入组的肿瘤缓解情况、肿瘤缩小率、出血量均优于静脉化疗组,但差异无统计学意义。3组术前化疗患者均不同程度出现不良反应,以静脉化疗组明显,但差异无统计学意义。结论:选择合适的化疗方案,可提高宫颈癌患者的手术切除率,降低费用。
Objective To compare the effect and adverse reaction of three different regimens of preoperative neoadjuvant chemotherapy in patients with cervical cancer. Methods Retrospective analysis of 1175 cervical cancer patients with FIGO stage Ⅰb2- Ⅱb were preoperative adjuvant chemotherapy in our hospital during 1996-2010. Tumor response, reducation ratio after neoadjuvant chemotherapy, side effects, complications, hemorrhage volume in surgery and operation ratio were statistically analyzed. Results 256 cases of the abdominal-wall-artery group had surgery intubation, 352 cases of trans-arterial chemoembolization group had surgery intubation, and 287 cases of venous chemotherapy group had. Tumor response, reducation ratio and hemorrhage volume in surgery were significantly better in the abdominal-wall-artery group and the trans-arterial chemoembolization group than those in venous chemotherapy group, but no significant ditterence was found in the three groups; There were different degree side effects in the three groups, in which venous chemotherapy group was obviously, but there was on statistical difference. Conclusion Choosing suitable chemotherapy regimens can improve the operation excision ratio and reduce cost.
出处
《实用医学杂志》
CAS
北大核心
2012年第21期3562-3565,共4页
The Journal of Practical Medicine
关键词
宫颈肿瘤
术前辅助化疗
Cervical cancer
Preoperative neoadjuvant chemotherapy
