摘要
背景与目的:在晚期肺癌患者中女性的预后好于男性,本研究探讨可切除的非小细胞肺癌的临床特征、病理、生存期与性别的关系。方法:平行对照2005年6月—12月上海市胸科医院初治的261例可完全手术切除的原发性非小细胞肺癌患者资料,其中女性125例,男性136例。分析患者的性别在吸烟史、家族肿瘤病史、初发疾病的状况、临床类型、病理类型、肿块直径、手术范围、术后期别及肺功能参数、术后治疗方面的差异,随访生存期至2012年6月。采用SPSS 19.0统计软件建立数据库,统计模式为t检验、χ2检验,Kaplan-Meier分析生存期与性别的相关,COX回归分析影响生存期的因素。结果:本组患者中女性吸烟率为4%,腺癌为女性的主要病理类型,多为周围型,病灶较小、肺功能明显好于男性,女性术后辅助化疗低于男性,肿瘤复发后EGFR-TKI治疗明显高于男性。女性肺癌患者和男性肺癌患者中位生存期分别为63个月和60个月,差异有统计学意义(P=0.044)。COX回归分析发现病理、分期、手术范围与生存期密切相关。结论:女性肺癌的临床特征不同于男性,生存期长于男性,但在可切除非小细胞肺癌中影响长期生存的因素仍是病理、期别和手术范围。
Background and purpose： Female with advanced non-small cell lung cancer （NSCLC） are more likely to have better survival then men. This study was to investigate the gender difference in characteristic and survival in resected NSCLC. Methods： All the patients have received systematic examination to determine the clinical stage from Jun. 2005 to Dec. 2005. Data regarding smoking status, family history of cancer, the symptoms in the diagnosis, clinic type, the diameter of lesions, stage, extent of operations, chemotherapy and EGFR-TKI treatment and MST. SPSS 19.0 was used for statistical analysis. Results： There were 136 men （51.7%） and 125 women （48.3%）. Only 4% of women were current smokers. Women were found to be more likely to have adenocarcinoma with peripheral type, smaller mean diameter of lesions, better mean data of the percentage of force volume capacity （FVC）, first-second exhale volume （FEV1）, maximal voluntary ventilation （MVV）, and better median survival of 63 months vs men of 60 months （P=0.044）. COX regression analysis found that pathology, stage, extent of operation closely related to the survival. Conclusion： Our study suggested Chinese female lung cancer has difference clinical characteristics and better survival in resected NSCLC, but pathology, stage, extent of operation were more important prognostic factors.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2012年第11期825-830,共6页
China Oncology
关键词
非小细胞肺癌
性别
预后
Non-small cell lung cancer
Gender
Prognosis
