摘要
神经生长因子(NGF)是神经营养素/因子家族中发现最早、研究最深入的神经生长调节因子,通过其受体介导在神经系统和非神经系统发挥生物学效应。溃疡性结肠炎(UC)是一病因未明但与肠道免疫异常有关的炎性疾病,NGF及其受体在UC时表达上调,可以发挥抗炎的保护性作用。NGF通过调控免疫细胞活性、参与炎症反应而发挥抗炎作用。将外源性NGF用于UC进行实验性治疗,可能是一种有益的探索,有可能为UC的治疗提供新的思路。
Nerve growth factor（NGF）,one of nerve growth regulatory factors in neurotrophin/factor family,effects biologically in nervous and non-nervous systems through its receptors-mediated transmission of information.Ulcerative colitis（UC）is an inflammatory disease,the pathogensis of which is still unknown but related to abnormal intestinal immunity.NGF and its receptor,up-regulated in UC,play a protective role in anit-inflammation.It is though up-regulating the activity of immune cells and involving in inflammatory response that NGF plays an anti-inflammatory part.Exogenous NGF in UC experimental treatment may be a useful exploration providing a new idea for UC treatment.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第33期3809-3812,共4页
Chinese General Practice
基金
甘肃省自然科学基金资助项目(1010RJZA089)
关键词
神经生长因子
溃疡性
结肠炎
肠神经系统
Nerve growth factor
Colitis
ulcerative
Enteric nervous system
