摘要
目的评价阿托伐他汀在治疗颈动脉粥样硬化斑块中的临床价值。方法将巩义市人民医院收治的192例经彩超检测存在颈动脉粥样硬化及斑块形成的脑梗死患者随机分为对照组和治疗组，每组96例，对照组予以口服抗血小板药物阿司匹林100mg/d，并采取控制血压和血糖等措施，治疗组在对照组的基础上予以阿托伐他汀20mg/d。6个月为1个疗程，治疗2个疗程，并对两组患者治疗前、治疗6个月和12个月后的颈动脉内膜-中层厚度、斑块面积及斑块性质数量进行比较。结果两组患者在治疗后6个月和治疗后12个月的颈动脉内膜-中层厚度和斑块面积显著低于治疗前（P〈0．05）。而治疗组在治疗后6个月和治疗后12个月的颈动脉内膜-中层厚度和斑块面积显著低于同期对照组（P〈0．05）。两组患者在治疗6个月和12个月后两纽扁平斑、硬斑及混合斑的数量比较差异无统计学意义（P〉0．05），但治疗组的软斑数量显著少于治疗前（P〈0．05）。结论阿托伐他汀能够有效地降低血脂水平，不仅缺血性脑血管病患者颈动脉硬化的程度得到减缓，还可以起到稳定斑块的作用。
Objective To evaluate the clinical value ot atorvastatm m treatment ot carotlo atner- osclerosis plaques. Methods One hundred and ninty-two patients who were diagnosed as cerebral stroke caused by carotid atheroselerosis plaques via check of color doppler sonography were divided into treat- ment group and control group randomly, with 96 eases in each group. Patients in control groups were giv- en persral antiplatelet agents（aspirin） 100 rag/d, and were taken measure to control blood pressure and blood sugar. Patients in treatment group were given atorvastatin 20 mg/d besides the same treatment as control groups. One course of treatment was 6 months, all patients receives two courses of treatment. Ca- rotid artery intima-media thickness, area of plaque and quantity of plaques were compared between the two groups at the time of before treatment, one course of treatment and two courses of treatment. Results Carotid artery intima-media thickness and area of plaques at the time of one course and two courses of treatment were lower than the time of before treatment significantly （P 〈 0.05 ） , and treatment group were lower than control groups significantly （P 〈 0.05 ）. The quantity of applanate plaques, hard plaques and compound plaques in two groups at the time of one course and two courses of treatment showed no statistical significance （P 〉0. 05 ）, soft plaques in treatment were less than control group （P 〈 0.05）. Conclusions Atorvastatin could lower blood lipid levels effectively not only slow down the degree of carotid atherosclerosis, and can stabilize the extension of plaques.
出处
《中国实用医刊》
2012年第23期56-58,共3页
Chinese Journal of Practical Medicine
关键词
颈动脉粥样硬化斑块
脑梗死
药物治疗
阿托伐他汀
Carotid atherosclerosis plaques
Cerebral stroke
Medication therapy
Atorvastatin
