摘要
目的探讨琥珀酸美托洛尔缓释微囊的制备工艺。方法以乙基纤维素作为囊材,采用乳化-溶剂扩散法,应用均匀设计优化处方和制备工艺,并研究其体外释药特性。结果在优化条件下制备的琥珀酸美托洛尔缓释微囊,外形圆整光滑,分布均匀,不粘连,平均粒径为80～90μm,包封率达83.16%,18 h体外释放百分率为96.1%。结论优化条件下可制备的缓释微囊外观较好、包封率高,在体外具有良好的缓释效果。
OBJECTIVE To prepare sustained-release microcapsules of metoprolol succinate（MS） and to investigate the influen- cing factors. METHODS The sustained-release microcapsules of metoprolol succinate were prepared with ethyl cellulose （EC） in one step by the emulsion-solvent diffusion method. Uniform design was used to optimize the formulation and preparation technique. Its re- lease behavior in vitro was studied. RESULTS All microcapsules prepared under the optimum condition were spherical and smooth with the mean particle size in the range of 80 -90 μm. The entrapment efficiency was 83.16% and drug release from the MS microcap- sules during 18 h reached 96. 1% in vitro. CONCLUSION The microcapsules have good morphological characteristics, high entrap- ment efficiency and sustained-release effect in vitro.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2012年第23期1920-1924,共5页
Chinese Pharmaceutical Journal
关键词
琥珀酸美托洛尔
缓释微囊
乳化-溶剂扩散法
体外释药
metoprolol succinate
sustained-release microcapsule
emulsion-solvent diffusion method
release behavior in vitro
