摘要
目的探讨老年2型糖尿病患者不同糖化血红蛋白(HbA1c)与动脉僵硬度的关系。方法选择老年2型糖尿病患者108例,根据年龄分为60～69岁组39例,70～79岁组39例,80～89岁组30例。以HbA1c作为评分标准:分为血糖控制不佳患者56例和血糖控制良好患者52例。以颈动脉-股动脉脉搏波传导速度(cfPWV)作为评价动脉僵硬度指标,进行cfPWV及下肢动脉多普勒超声、血脂检测,并进行相关因素分析。结果 60～69岁组、70～79岁组、80～89岁组血糖控制不佳患者cfPWV、LDL-C、TG水平明显高于血糖控制良好患者,差异有统计学意义(P<0.05,P<0.01)。回归分析显示,cfPWV与HbA1c、甘油三酯呈正相关(r=0.652,r=0.425,P=0.000)。结论血糖控制不佳是老年2型糖尿病患者动脉僵硬度增加的重要危险因素。
Objective To study the relation between glycosylated hemoglobin（HbAlc） and arterial stiffness in elderly patients with type 2 diabetes mellitus（DM）. Methods One hundred and eight elderly patients with type 2 DM,enrolled in this study,were divided into 60-69 years old group （n=39）,70-79 years old group（n=39）,and 80 89 years old group（n=30） according to their age, and further divided into poor HbAlc control group（n=56） arid good HbAlc control group （n=52） according to their HbAlc level. Their carotid and femoral artery pulse ave velocity （cfPWV） ,lower limb arterial Doppler ultrasonoraphy and lipid were recorded with the cfPWV as an indication for the assessment of arterial stiffness and analyzed by multiple factor correlation analysis. Results The cfPWV, LDL-C and TG levels were significantly higher in poor HbAlc control group than in good HbAlc control group（P〈0.05, P〈0.01）. Logistic regression analysis showed that the cfPWV was positively related with the HbAlc and TG（r=0. 652,r= 0. 425,P= 0. 000）. Conclusion Poor blood glucose control is an important risk factor for the aggravated arterial stiffness in elderly patients with type 2 DM.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2012年第12期1235-1237,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
糖尿病
2型
血红蛋白A
糖基化
动脉硬化
血糖
脂代谢障碍
危险因素
diabetes mellitus, type 2
hemoglobin A, glycosylated
arteriosclerosis
blood glucose
lipid metabolism disorders
risk factors
