摘要
肝癌是一种恶性程度高的肿瘤,临床上缺乏有效的治疗方法。有确切的证据表明肿瘤干细胞(CSCs)不仅与肿瘤的启动有关,且与肿瘤的远处转移和术后复发相关。最近,肝内CSCs的研究引起了人们的广泛关注,作为一种肿瘤起始细胞,其广泛存在于肝癌患者肿瘤组织和外周循环中。肝脏CSCs的特性(如自我更新、无限增生和分化)与肝癌的复发和药物抵抗高度相关,这些都是肝癌治疗效果不佳的根本原因。现就CSCs的概念、特征、肝内CSCs的来源、自我更新能力的调控及基于CSCs靶向治疗肝癌的重要策略等进行综述。
Hepatocellular carcinoma is a highly malignant tumor lack of effective clinical treatments.The compelling evidence has suggested that cancer stem cells（CSCs）are responsible not only for tumor initiation but also for the generation of distant metastasis and recurrence.Recently,CSCs in liver have attracted extensive attention as a tumor-initiating cell demonstrated in liver cancer tissues and peripheral circulation of hepatocellular carcinoma patients.Moreover,liver CSCs properties such as self-renewal,unlimited proliferation and differentiation are highly relevant to cancer recurrence and the drug resistance,which are attributed to the poor effects of HCC treatment.Here is to make a review on the concept,characteristics of liver CSCs,and summarize the origin,regulation of self-renewal of CSCs in liver and the strategy of CSCs-targeted therapy for hepatocellular carcinoma.
出处
《医学综述》
2012年第22期3775-3777,共3页
Medical Recapitulate
关键词
肿瘤干细胞
肝癌
治疗
Cancer stem cells
Liver carcinoma
Treatment
