摘要
探讨根治放射治疗对青少年鼻咽恶性肿瘤远期生存质量的影响。方法 5 1例年龄 <18岁的青少年鼻咽恶性肿瘤在本院接受根治放射治疗 ,随访超过 10年。结果 10年生存率为 5 1.0 %。成年后平均身高、体重男性为 1.6 6m ,5 7kg ,女性为 1.5 5m ,5 3kg。 11人已结婚生育 ,后代均正常。无癌生存 2 6例中后遗症为面部放射性皮炎 2例 (7.7% )、龋牙 6例 (2 3 .1% )、传导性耳聋2例 (7.7% )、颈部放射性皮炎 5例 (19.2 % )、垂体功能减退 2例 (7.7% )。结论 根治性放射治疗对青少年鼻咽恶性肿瘤远期生长发育影响不大 ,较合适的剂量为鼻咽部 6 7～ 6 8Gy ,上颈部 5 5～ 6 5Gy ,下颈部 45～ 5 0Gy。要注重康复期的心理治疗。
Objective To evaluate the effect of radical radiotherapy on long-term life quality of young adolescent patients with nasopharyngeal malignant neoplasms.Methods From February 1978 to September 1987, 51 patients younger than 18 years were treated with radical radiotherapy for nasopharyngeal malignant neoplasms. All patients were followed for more than ten years. Results The overall 10-year survival was 51.0% (26/51). When these patients grew up, the mean height and weight were 1.66 meters and 57 kilograms for male, and 1.55 meters and 53 kilograms for female. Eleven of them were married and had normal children. Twenty-six patients who survived without disease had the long-term side-effects such as radiodermatitis of head and neck (7 patients), dental caries (6 patients), conduction deafness (2 patients) and pituitary insufficiency (2 patients). Conclusions Radiotherapy does not significantly influence the growth of young patients with nasopharyngeal malignant neoplasms. The appropriate radiation doses were 67～68 Gy to the nasopharynx, 55～65 Gy to the upper neck, and 45～50 Gy to the lower neck.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2000年第2期77-79,共3页
Chinese Journal of Radiation Oncology
关键词
鼻咽肿瘤
放射疗法
生存质量
青少年
Nasopharyngeal neoplasms/radiotherapy
Living quality
