摘要
目的:探讨细胞因子基因表达与胃癌发病的相关性。方法:采用限制性片段长度多态性分析(PCR-RFLP)和序列特异性PCR(SSP)法,分析胃癌患者及健康对照者外周血单核细胞基因多态性的表达。结果:胃癌组-31T/T、-511C/C的频率明显升高(P<0.01),IL-1ra基因型,以1/1基因型频率最高,但各基因型在对照组和病例组中出现的频率无显著性差异(P>0.05)。结论:IL-1等细胞因子基因表达的多态性与胃癌发病密切相关。
Objective：To investigate the correlation of cytokine gene expression and gastric cancer.Methods：using restriction fragment length polymorphism analysis（PCR-RFLP） and sequence specificity of PCR（SSP） method,analysis of gastric cancer patients and healthy controls in peripheral blood mononuclear cells gene expression.Results：Gastric Cancer Group-31T / T,511C/C frequency was significantly elevated（P0.01）,IL-1ra genotype,1 /1genotype frequency was higher,but the genotype in the control group and a group of frequency of occurrence without significant difference（P0.05）.Conclusion：IL-1and cytokine gene expression polymorphism and gastric cancer are closely related.
出处
《中国医药导刊》
2012年第10期1685-1685,1687,共2页
Chinese Journal of Medicinal Guide
关键词
细胞因子
基因多态性
胃癌
Cytokine
Gene Polymorphisms
Gastric Cancer
