摘要
目的探讨降钙素原（PCT）的测定在颅内感染患者中的诊断价值和临床意义。方法随机抽取急性脑膜炎患者62例作为研究对象，并按照其感染类型不同分为细菌性脑膜炎组和病毒性脑膜炎组，分不同时期测定其血清降钙素原（PCT）数值以及脑脊液分析。结果细菌性脑膜炎在急性发病期，PCT值为（26．43±15．32）μg／L，显著高于正常值，经过治疗后3d、5d、7d，其PCT值分别为（5．85±5．43）μg／L、（0．21±0．26）μg／L、（0．06±0．12）μg／L，较治疗前明显降低（P〈0．05）。而病毒性脑炎组PCT在急性感染期和治疗后3dPCT水平分别为（1．64±3．25）μg／L、（0．83±3．12）μg／L，明显低于细菌性脑膜炎组（P〈0．05）；两组患者CRP水平分别为（28．3±15．3）mg／L、（27．3±16．4）mg／L，无统计学差异（P〉0．05），CSF白细胞数分别为（287±15）×10^6、（17±5）×10^6、CSF蛋白分别为（1.68±0．36）mg／L、（0．67±0．32）mg／L，差异有显著性（P〈0．05），但两组有重叠。结论血清降钙素原的测定在于早期鉴别诊断细菌性脑膜炎和病毒性脑炎上有着重要的临床意义。
Objective To investigate the values and clinical significance of procalcitonin （ PCT ） determination in the diagnosis of intracranial infection. Methods 62 patients with acute meningitis were divided into bacterial meningitis group and viral meningitis group according to the type of infection. Serum PCT levels were detected at different stages of meningitis and cerebrospinal fluid was analyzed. Results PCT levels were （ 26.43 ± 15.32 ） μg/L in the acute phase of bacterial meningitis and significantly higher than the normal level; after treatment, they were （ 5.85 ± 5.43 ） μg/L on day 3, （ 0.21 ± 0.26 ） μg/L on day 5, and （ 0.06 ± 0.12 ） μg/L on day 7, being significantly reduced （ P〈 0.05 ）. PCT levels were （ 1.64 ±3.25 ） μg/L in the acute phase and （ 0.83 ± 3.12 ） μg/L on day 3 in viral encephalitis group, which were significantly lower than those in bacterial meningitis group （ P 〈 0.05 ）. CRP levels did not differ significantly between the two groups [（ 28.3 ± 15.3 ） （ 5-110 ）mg/L vs. （ 27.3 ± 16.4 ） （ 0-45 ） mg/L, P〉 0.05]. There were significant differences between the two groups in leukocyte count and protein level in CSF [（ 287 ± 15 ） （ 24 - 590 ） ×10^6 vs. （ 17 ± 5 ） （ 6-120 ） ×10^6 and （ 1.68 ± 0.36 ） （ 0.4-4.8 ） mg/L vs. （ 0.67 ± 0.32 ） （ 0.1-2.5 ） mg/L, P〈 0.05], but there was a overlap in the two groups. Conclusions Serum procalcitonin determination has important clinical significance in the early differential diagnosis of bacterial meningitis with viral encephalitis.
出处
《国际医药卫生导报》
2012年第21期3164-3166,共3页
International Medicine and Health Guidance News
关键词
降钙素原
颅内感染
临床意义
Procalcitonin
Intracranial infection
Clinical significance
