摘要
目的检测细菌性肠炎和病毒性肠炎患儿血清中降钙素原(Procalcitonin,PCT)和C反应蛋白(C-reactive protein,CRP)水平,探讨其在小儿肠炎诊断中的应用价值。方法选取2012年6月至2014年4月我院收治的腹泻患儿300例作为研究对象,其中细菌性肠炎患儿187例(细菌组),病毒性肠炎患儿113例(病毒组)。检测两组患儿血清PCT和CRP水平,并分析两者对小儿肠炎的诊断价值。结果细菌组患儿血清中PCT和CRP水平显著高于病毒组,差异均具有统计学意义(P<0.05)。PCT和CRP对细菌性肠炎诊断的阳性率分别为88.23%和82.89%,显著高于对病毒性肠炎诊断的阳性率。PCT对细菌性肠炎诊断的敏感度、特异度、准确度、阳性预测值和阴性预测值均高于CRP;PCT联合CRP诊断细菌性肠炎的敏感性稍有降低,但是特异性却大大提高。结论细菌性肠炎患儿血清中PCT和CRP水平均有明显升高,两者对小儿肠炎的诊断具有重要的参考价值。
Objective To evaluate the levels of Procalcitonin（PCT）and C-reactive protein（CRP）as markers in diagnosis of infection in bacillary enteritis（BE）and viral enteritis（VE）.Methods 187 children with BE（BE group）and 113 children with VE（VE group）were enrolled in this study.The levels of PCT and CRP in serum were measured in all groups,and the diagnostic values of PCT and CRP were evaluated.Results The levels of PCT and CRP in BE group were significantly higher than in VE group（P〈0.05）.The positive rates of PCT and CRP in diagnosing BE were 88.23% and 82.89%,significantly than that in diagnosing VE.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of PCT in diagnosing BE were higher than CRP;the sensitivity of PCT combined with CRP in diagnosing BE was slightly fell,but the specificity was increased greatly.Conclusion The levels of PCT and CRP were significantly elevated in serum of children with BE,and the two markers may be of value in diagnosis of BE and VE.
出处
《中国实验诊断学》
2015年第10期1702-1704,共3页
Chinese Journal of Laboratory Diagnosis
关键词
降钙素原
C反应蛋白
细菌性肠炎
病毒性肠炎
小儿
Procalcitonin
C-reactive protein
bacillary enteritis
viral enteritis
pediatric
