精蛋白生物合成人胰岛素注射液与口服降血糖药联合用药治疗2型糖尿病患者的临床效果观察被引量：2

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摘要目的研究精蛋白生物合成人胰岛素注射液(诺和灵N)与口服降血糖药联合用药治疗2型糖尿病患者的临床效果。方法将2011年1月～2012年1月来本院内分泌科就诊的174例单纯口服降糖药未能控制血糖水平的2型糖尿病患者随机分为观察组和对照组各87例,其中观察组给予精蛋白生物合成人胰岛素注射液与口服降血糖药联合用药,对照组仅给予口服降糖药进行治疗。结果两组患者在治疗前和治疗后4周餐后2h血糖(2hPG)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)水平差异均无统计学意义(P>0.05),治疗后8周观察组患者在2hPG、FBG、HbA1c水平均明显低于对照组,差异有统计学意义(P<0.05)。观察组患者发生1例低血糖,对照组无低血糖发生,两组低血糖发生率差异无统计学意义(χ2=0.16,P>0.05)。结论精蛋白生物合成人胰岛素注射液与口服降血糖药联合用药治疗单纯药物治疗血糖控制不理想的2型糖尿病患者能明显改善其血糖水平,并且低血糖发生率较低,因此值得临床推广应用。

作者赖鸿鹄

机构地区广东省高州市人民医院内分泌科

出处《中国当代医药》 2012年第21期89-90,共2页 China Modern Medicine

关键词 2型糖尿病中效胰岛素临床效果联合用药

分类号 R977.15 [医药卫生—药品]

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