摘要
目的探讨降压药物对高血压性脑出血患者围术期血流动力学的影响。方法选取我院2009年1月～2011年7月收治的高血压性脑出血患者78例,随机分为两组,采用乌拉地尔治疗的39例患者为对照组,采用尼莫地平治疗的39例患者为观察组,比较两组患者围术期血流动力学的变化情况。结果泵药后,对照组心率略有升高,收缩压和舒张压均明显降低;观察组心率先升高后明显降低,收缩压和舒张压均明显降低;观察组心率、收缩压、舒张压均明显低于对照组。术中,对照组心率略有降低,收缩压和舒张压均明显降低;观察组心率略有升高,收缩压和舒张压均明显降低;观察组收缩压、舒张压均明显低于对照组。术后72 h,观察组平均血流量、平均血流速度均明显高于对照组,观察组外周阻力、临界压力均明显低于对照组,差异均有统计学意义(P<0.05)。结论尼莫地平用于高血压性脑出血患者的降压治疗,可以明显增加患者的脑血流量,并降低患者的脑血管阻力,还能有效控制患者术后的血压状况,临床疗效显著,值得临床推广使用。
Objective To investigate the influence of antihypertensive drugs on perioperative hemodynamics of patients with hypertensive cerebral hemorrhage.Methods 78 patients with hypertensive cerebral hemorrhage were selected in the hospital from January 2009 to July 2011,who were randomly divided into two groups.39 patients who used Urapidil were as the control group.39 patients who used Nimodipine were as the observation group.The perioperative hemodynamics changes of two groups were compared.Results After pump delivery,heart rate was improved slightly,while systolic blood pressure and diastolic blood pressure were significantly reduced in the control group.The heart rate was significantly reduced after slightly elevated,while systolic blood pressure and diastolic blood pressure were significantly reduced in the observation group.The heart rate,systolic blood pressure and diastolic blood pressure in the observation group were significantly lower than those in the control group.During the operation,heart rate was decreased slightly,while systolic blood pressure and diastolic blood pressure were significantly reduced in the control group.The heart rate was slightly elevated,while systolic blood pressure and diastolic blood pressure were significantly reduced in the observation group.Systolic blood pressure and diastolic blood pressure in the observation group were significantly lower than those in the control group.After the operation of 72 h,mean blood flow,mean flow velocity in the observation group were significantly higher than those in the control group,while peripheral resistance,critical pressure in the observation group were significantly lower than those in the control group.The differences were statistically significant（P 0.05）.Conclusion Nimodipine can be used as antihypertensive treatment for patients with hypertensive cerebral hemorrhage,which can significantly increase cerebral blood flow and reduce cerebral vascular resistance.That can effectively control blood pressure status of patients after operatio
出处
《中国医药导报》
CAS
2012年第26期71-72,75,共3页
China Medical Herald
基金
河北省石家庄市科学技术研究与发展计划课题(课题名称:高血压脑出血手术方式的选择
课题编号:111461463)
