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超敏C反应蛋白联合降钙素原对鉴别感染性和恶性胸腔积液的有效性分析 被引量:6

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摘要 目的:探讨超敏C反应蛋白(HS-CRP)与降钙素原(PCT)检测在鉴别感染性和恶性胸腔积液的作用。方法:选取胸腔积液患者96例(明确病因后分感染及恶性组),抽取胸腔积液,分别采用免疫比浊法及酶联荧光分析(ELFA)法检测HS-CRP及PCT浓度。结果:胸腔积液PCT、HS-CRP在感染性及恶性胸腔积液组中分别为[0.53(0.8~1.003)]ng/mL、[0.05(0.05~0.05)]ng/mL及(8.949±2.078)mg/L、(5.371±1.323)mg/L,两组比较,有统计学差异,P<0.05。在鉴别感染性与恶性胸腔积液中,胸腔积液PCT及HS-CRP诊断的曲线下面积在0.857以上,胸腔积液PCT联合HS-CRP诊断的曲线下面积为0.937。以恶性胸腔积液为对照,诊断感染性胸腔积液胸腔积液PCT的最佳诊断截点为0.055ng/mL,胸腔积液HS-CRP的最佳诊断截点为6.625mg/L。结论:胸腔积液PCT、HS-CRP及胸腔积液PCT联合HS-CRP检测在感染性及恶性胸腔积液的鉴别诊断中有一定作用,联合指标优于单个指标。胸腔积液PCT≥0.055ng/mL、HS-CRP≥6.625mg/L有助于鉴别感染性与恶性胸腔积液。
出处 《实用医学杂志》 CAS 北大核心 2012年第22期3787-3789,共3页 The Journal of Practical Medicine
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