摘要
目的观察中西医结合治疗成人过敏性紫癜(Henoch-Schonlein purpura,HSP)的临床效果。方法将60例成人HSP随机分为观察组(采用中西医结合方法治疗)和对照组(采用西医方法治疗),每组各30例。观察两组治疗结束后临床症状改善情况、不良反应情况,治疗结束后6个月内HPS复发率、紫癜性肾炎(Henoch-Schnlein purpura nephritis,HSPN)发生率,治疗前后血清IgA、补体C3、尿微量白蛋白水平变化。结果皮疹消退时间及住院时间,观察组分别为(6.0±2.1)d、(12.0±3.3)d,对照组分别为(7.0±2.3)d、(13.0±3.5)d,两组比较差异无统计学意义(P>0.05);治疗过程中两组均无明显不良反应。治疗结束后6个月内HSP复发率和HSPN发生率,观察组分别为23.3%(7/30)、20.0%(6/30),对照组分别为50.0%(15/30)、83.3%(25/30),两组比较差异有统计学意义(P<0.05)。治疗结束后观察组血清IgA、补体C3水平基本恢复正常,与对照组比较差异有统计学意义(P<0.05);尿微量白蛋白显著降低,与对照组比较差异亦有统计学意义(P<0.05)。结论中西医结合治疗HSP效果良好,且可减少HSP复发率及HSPN发生率。
Objective To investigate the clinical efficacy of combined therapy of traditional Chinese and Western Medicines in treatment of henoch schonlein purpura （HSP） in adult. Methods Patients with allergic purpura were randomly divided into the therapy group （combined therapy of traditional Chinese and western medicines） and control group （western medicine therapy） （n = 30 in each goup）. The improvement of clinical symptoms, adverse reaction, HSP recurrence rate 6 months after treatment, incidence rate of Henoch- Schnlein purpura nephritis （HSPN） and the change of serum IgA level , alexine C3 Urine ALB of the two groups were observed. Results The rash subsided time and hospital stay of observation group were （ 6. 0 ± 2.1 ） days and （ 12. 0 ± 3.3） days respectively, while those of control group were （7.0±2.3）days and （13.0 ±3.5） days respectively, and the differences were not statistically significant （P 〉0.05 ）; no significant adverse drug reaction occurred during the treatment. After 6 months of treatment the recurrence rates of HSP and HSPN in therapy group were 23.3% （7/30） and 20.0% （6/30） respectively, while those of control group were 50.0% （15/30） and 83.3% （25/30） respectively, and the difference were statistically significant （P 〈0.05）. After treatment the level of serum IgA and alexine C3 in therapy group that of control gn）up （P 〈0. 05） ; and level of returned to basically normal level with significant difference compared with Urine ALB in therapy group was significantlly reduced compared with that of control group （P 〈0. 05）. Conclusion Combination treatment of traditional Chinese and western medicines may reduce the recurrence rate of HSP and the occurrence of Henoch-Schonlein DurDura nephritis.
出处
《临床误诊误治》
2012年第11期84-87,共4页
Clinical Misdiagnosis & Mistherapy
基金
河北省科技支撑计划项目课题(JB00 10276188)
关键词
紫癜
过敏性
成人
中西医结合疗法
Purpura, hypersensibility
Adult
Integrated Chinese-western therapy
