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孟鲁司特治疗成人咳嗽变异型哮喘的临床观察 被引量:10

Clinical observation on the treatment of cough variant asthma by using montelukast
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摘要 目的观察孟鲁司特治疗成人咳嗽变异性哮喘(cough variant asthma,CVA)的疗效及其对峰呼气流速PEF变异率的影响。方法 34例CVA患者给予孟鲁司特10 mg,每日1次,疗程4周,测定患者治疗前、治疗后2周、4周的咳嗽频率评分,峰呼气流速PEF变异率,以及诱导痰嗜酸性粒细胞计数。结果治疗后4周患者咳嗽频率评分有显著改善。治疗后第2周、第4周PEF变异率较治疗前均有显著改善,诱导痰嗜酸性细胞计数较治疗前显著减少。结论孟鲁司特能明显降低气道炎症,治疗咳嗽变异性哮喘疗效确切。 Objective To evaluate the effectiveness of montelukast in the treatment of cough variant asthma and the influence on PEF variation. Methods 34 CAV patients were treated with montelukast 10 mg once a day for 4 weeks. Cough frequency scores, variation of PEF and induced sputum EOS were recorded. Results The cough frequency was significantly reduced. By the end of second week and fourth week there was a significant decrease in the PEF variation and induced sputum EOS level. Conclusion Montelukast can reduce airway inflammation and it is effective in the treatment of cough variant asthma.
出处 《临床肺科杂志》 2012年第12期2164-2165,共2页 Journal of Clinical Pulmonary Medicine
关键词 咳嗽变异性哮喘 药物治疗 孟鲁司特 诱导痰 嗜酸性粒细胞 cough variant asthma drug therapy montelukast induced sputum eosinophils
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