摘要
目的探讨依达拉奉对急性脑梗死患者血清中内皮素（ET）、可溶性细胞间黏附分子1（sICAM一1）和单核细胞趋化因子1（MCP一1）以及神经功能的影响。方法将急性脑梗死患者随机分为治疗组和对照组，对照组给予常规治疗，治疗组另加用依达拉奉。采用ELESA法检测治疗前后血清ET、sICAM．1及MCP．1水平，并进行神经功能缺损（NDS）评分。结果急性脑梗死患者血清ET、sICAM-1及MCP-1水平较健康对照组明显升高（t=4．55、4．62、4．75、4．43、4．61、4．73，均P〈0．05）；治疗后两组血清ET、ICAM．1、MCP．1水平及NDS评分均较治疗前下降（t=4．12、4．23、4．15、3．91、3．92、3．83、4．52、4．36，均P〈0．05），且治疗组较对照组下降明显（t=3．72、3．63、3．53、3．72，均P〈0．05）。结论依达拉奉可显著降低急性脑梗死患者ET、sICAM-1及MCP-1的表达，减轻脑组织炎性反应，对脑细胞起保护作用。
Objective To explore the influence of edaravone on serum endothelin（ET） ,soluble intercellular adhesion moleculel （sICAM-1） and monocyte chemotactic factor 1 （MCP-1） and neurological function in acute cere- bral infarction patients. Methods 90 patients with acute cerebral infarction were randomly divided into treatment group（additional edaravone） and control group （routine treatment）. The serum levels of ET, sICAM-1 and MCP-1 were detected by ELESA pretherapy and after treatment. Neurological functional deficit scores（NDS） was utilized for assessment pretherapy and after treatment. Results The levels of serum ET,sICAM-1 and MCP-1 in acute cerebral infarction groups were significantly higher than those of control group（ t = 4.55,4.62,4.75,4.43,4.61,4.73, all P 〈 0.05） ;The levels of serum ET, sICAM-1 and MCP-1, NDS in both two groups after treatment were significantly lower than those before treatment （ t = 4.12,4.23,4.15,3.91,3.92,3.83,4.52,4.36, all P 〈 0.05 ）, and the levels of ser- um ET,sICAM-1 ,MCP-1 and NDS in the treatment group were significantly lower than those in the control group（ t = 3.72,3.63,3.53,3.72,all P〈0.05）. Conclusion Edaravone can decrease the levels of ET,sICAM-1 and MCP-1 in acute cerebral infarction patients. It can lighten acute inflammation and brain injury, protect the tissue of brain.
出处
《中国基层医药》
CAS
2012年第23期3562-3563,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
急性脑梗死
内皮素
可溶性细胞间黏附分子
单核细胞趋化因子
依达拉奉
Cerebral infarction
Endothelin
Soluble intercellular adhesion molecule 1
Monocyte chemotactic factor 1
Edaravone
