摘要
肿瘤干细胞位于特定的微环境中，这些微环境在肿瘤细胞的增殖和转移中起到了重要的作用。缺氧是实体肿瘤组织微环境重要的特征之一，最近一系列研究结果表明缺氧微环境下可能是肿瘤干细胞促进肿瘤转移的重要环节，这一结果为理解肿瘤的发生机制和治疗肿瘤提供了新的线索。
Cancer stem cells located in specific microenvironment, that play an important role in the proliferation ,and metastasis of tumor cells. Hypoxia is one of the important features of tumor tissue microenvironment. A series of studies results show that the hypoxic microenvironment of tumor stem cells could promote tumor metastasis, which provides new clues for understanding tumor pathogenesis and tumors treatment.
出处
《国际肿瘤学杂志》
CAS
2012年第11期812-814,共3页
Journal of International Oncology
关键词
肿瘤干细胞
缺氧
缺氧诱导因子1
肿瘤转移
Neoplastic stem cells
Anoxia
Hypoxia-inducible factor 1
Neoplasm metastasis
