摘要
目的:研究安胃丸对慢性胃炎模型大鼠的保护作用。方法:连续12周灌胃60%的乙醇(每周2次)、20mmol·L-1的去氧胆酸钠,饮用0.05%的氨水以复制慢性胃炎大鼠模型。实验分为6组,即正常对照(等容生理盐水)、模型(等容生理盐水)、胃乃安(0.64g·kg-1)与安胃丸高、中、低剂量(12.24、6.12、3.06g·kg-1)组,灌胃给药,每天1次,连续30d。观察大鼠胃黏膜病理变化与胃酸、胃蛋白酶、游离黏液含量变化。结果:与模型组比较,安胃丸组游离酸、总酸、游离黏液含量与胃蛋白酶活性显著降低(P<0.01或P<0.05);胃黏膜病理改变减轻,炎细胞浸润减少,黏膜炎症评分显著下降(P<0.05),胃窦黏膜腺体厚度(L1)与黏膜肌层厚度(L2)之比(L1/L2)无明显差别(P>0.05)。结论:安胃丸对大鼠慢性胃炎有一定防治作用。
OBJECTIVE：To study the protective effect of Anwei pills on chronic gastritis model rats.METHODS：Chronic gastritis model was established by intragastric administration of 60% ethanol,20 mmol·L-1 sodium deoxycholate and 0.05% ammonia water.Model rats were divided into 6 groups,i.e.normal control group（constant volume of normal saline）,model group（constant volume of normal saline）,Weinaian（0.64 g·kg-1） and Anwei pills high-dose,medium-dose and low-dose groups（12.24,6.12 and 3.06 g·kg-1）.They were given medicine once a day for consecutive 30 days.Pathologic changes of gastric mucosa were observed,and levels of gastric juice,pepsase and free mucus were observed.RESULTS：Compared with model group,the concentrations of free acid,total acid and free mucus were significantly decreased in Anwei pills group（P0.01）,the activity of pepsase decreased significantly（P0.01）,pathologic changes of gastric mucosa were relieved,the infiltration of inflammatory cell decreased and mucosal inflammation score decreased significantly（P0.05）.The thickness of gastric mucosal gland and muscularis mucos（Ll/L2） were very close to model group（P0.05）.CONCLUSION：Anwei pills have the effect on prevention and treatment of chronic gastritis in rats.
出处
《中国药房》
CAS
CSCD
2012年第43期4052-4054,共3页
China Pharmacy
关键词
安胃丸
慢性胃炎
大鼠
Anwei pills
Chronic gastritis
Rats
