摘要
目的观察依那普利治疗原发性高血压的降压效果及其对原发性高血压病早期肾损害的疗效。方法选取原发性高血压病(EH)患者43例,在常规治疗(包括低盐饮食、适量运动、戒烟等)基础上给予依那普利治疗,连续8周,观察治疗前、后血压改善情况,检测尿微量白蛋白(u-ALB)和β2微球蛋白(β2-MG)水平,并与30名同期健康体检者进行对照(对照组)。结果依那普利治疗4周时,EH组患者血压明显下降(P<0.05,P<0.01),治疗8周后血压显著下降,甚至已基本接近正常水平(P<0.01);治疗后EH组患者u-ALB和β2-MG水平显著降低(P<0.01),与对照组比较,差异无统计学意义(P>0.05)。结论依那普利治疗轻、中度原发性高血压,降压作用明显、确切,患者耐受性好,且能降低尿微量白蛋白、β2微球蛋白含量,对肾脏具有一定的保护作用。
Objective To observe the antihypertensive effect of enalapril in treating essential hypertension（EH） and early renal damage. Methods Forty-three patients with EH were selected and given enalapril on the base of the conventional treatment including low- salt diet, proper exercise, smoking cessation, etc. for 8 continuous weeks. The improvement of blood pressure before and after treatment was observed. The urinary microalbumin （n-ALB） and β2 microglobulin （β2-MG） levels were detected and compared with contempo-rary 30 individuals of healthy physical examination as control. Results In 4-week enalapril treatment, blood pressure was decreased significantly（ P〈 0. 05, P〈 0. 01）. After 8-weeks treatment, blood pressure was significantly decreased and even closed to the normal level（ P 〈 0. 01）. After enalapril, u - ALB and β2 - MG were obviously decreased（ P 〈 0. 01 ）, but difference showing no statistical signifi-cance compared with the normal group（ P 〉 0. 05）. Conclusion Enalapril in the treatment of mild to moderate essential hypertension has obvious and definite antihypertensive effect with good tolerance, can reduce the u-ALB, β2-MG content and has a certain protec-tion effect on kidney.
出处
《中国药业》
CAS
2012年第21期61-62,共2页
China Pharmaceuticals
