摘要
目的 探讨轻中度高血压患者早期肾损害与血清尿酸浓度的关系。方法 100例轻中度高血压患者在检测血、尿β2 微球蛋白及尿白蛋白同时检测血清尿酸浓度,并分析血清尿酸与肾损害发生的关系。结果 血、尿β2 微球蛋白及尿白蛋白增高的患者血清尿酸分别为( 504. 8±28. 3 )mmol/L、(484. 6±75. 3)mmol/L、(492. 6±66. 3)mmol/L;血、尿β2 微球蛋白及尿白蛋白正常患者血清尿酸分别为(320. 9±102. 6)mmol/L、(380. 7±42. 6)mmol/L、(374. 9±43. 8)mmol/L。血清尿酸浓度≥420mmol/L患者血、尿β2 微球蛋白及尿白蛋白分别为(4. 28±1. 14)mg/L、(1. 2±0. 74)mg/L、(27. 9±9. 3)mg/L;血清尿酸浓度<420mmol/L患者血、尿β2 微球蛋白及尿白蛋白分别为( 2. 56±1. 44 )mg/L、( 0. 54±0. 11 )mg/L、(18. 4±6. 6)mg/L。结论 高血压患者合并血清尿酸增高,可加重肾损害;同时,高血压发生肾损害后可增加血尿酸浓度。
Objective To explore the relationship between the early renal injury in the slight and moderate hypertension patients with serum uric acid concentration.Methods Serum and urine β_2-microglobulin(β_2-MG),albumin and serum uric acid concentration were detected at the same time,the relationship between serum uric acid and renal injury was analyzed.Results Serum uric acid concentration in the patients with increased serum and urine β_2-MG and albumin were (504.8±28.3)mmol/L,(484.6±75.3)mmol/L and (492.6±66.3)mmol/L,respectively,which were (320.9±102.6)mmol/L,(380.7±42.6)mmol/L and (374.9±43.8)mmol/L in the patients with normal serum and urine β_2-MG and albumin.Serum,urine β_2-MG and albumine in the patients with serum uric acid≥420mmol/L were (4.28±1.14)mg/L,(1.2±0.74)mg/L,and (27.9±9.3)mg/L,respectively,which were (2.56±1.44)mg/L,(0.54±0.11)mg/L and (18.4±6.6)mg/L in the patients with serum uric acid<420 mmol/L.Conclusion Increased serum uric acid in hypertension patients may deterconte the renal injury,meanwhile increase the uric acid concentration.
出处
《中国综合临床》
北大核心
2005年第5期391-393,共3页
Clinical Medicine of China
关键词
高血压
血尿酸
肾损害
Hypertension
Serum uric acid
Renal injury
