摘要
目的分析乙型肝炎病毒(HBV)前S1抗原与HBV-DNA含量在反映HBV复制方面的相关性。方法采用酶联免疫吸附试验(ELISA)和聚合酶联反应(PCR)方法分别检测414例乙型肝炎患者的HBV-PreS1抗原和HBV-DNA,比较检出率。结果 414名患者中,HBeAg和HBV-PreS检测结果一致者64.5%,不一致者占36.5%,两种方法之间阳性率有统计学差异(χ2=53.33,P<0.05);HBeAg和HBV-DNA同时阳性130人,占63.8%,不一致者占33.2%,两种方法检测阳性率之间有统计学差异(χ2=66.13,P<0.05);HBV-DNA和HBV-PreS1检测结果一致者占94.9%,不一致者占5.1%,两种检测方法结果没有统计学差异(χ2=0.418,P>0.05)。结论 HBV-PreS1抗原与HBV-DNA呈高度相关,HBV-PreS1可作为HBV活动性复制指标。
Objective To analyze the correlation of HBV - PreS1Ag and HBV - DNA. Methods HBV - PreS1Ag and HBV - DNA of 414 HBV patients and 50 non - HBV people were detected by ELISA and PCR. The detection rate was compared. Results The detection rate of HBV - PreS1Ag and HBV - DNA in 414 HBV patients were 60.7% and 63.7%. The detection rate of HBV - PreS1Ag and HBV - DNA in HBeAg - positive group were 84.3% were 88.4%. The detection rate of HBV- PreS1Ag and HBV - DNA of HBeAg - negative group were 47.9% and 50.2%. Conclusion HBV - PreS1Ag and HBV - DNA were highly correlated. HBV - PreS1Ag is an index of HBV replication.
出处
《医学研究杂志》
2012年第10期101-103,共3页
Journal of Medical Research
基金
兰州大学中央高校基本科研业务费专项基金资助项目(lzujbky-290-146)
