摘要
目的研究脑脊液置换和鞘内注射异烟肼、糖皮质激素、尿激酶和胞二磷胆碱对老年中晚期结核性脑膜炎患者的疗效。方法于2007年10月1日至2012年3月31日住院的86例老年中晚期结核性脑膜炎患者,按是否鞘内注药分为治疗组(46例)和对照组(40例)。对照组给予常规药物治疗和置换脑脊液治疗;治疗组在常规药物治疗的基础上,给予脑脊液置换并鞘内注射异烟肼、糖皮质激素、尿激酶和胞二磷胆碱。根据2组脑脊液变化和临床疗效进行比较分析。结果治疗组治愈32例,有效10例,无效4例;对照组治愈16例,有效8例,无效16例。治疗组治疗效果明显高于对照组(P<0.05),且未发现与脑脊液置换加鞘内注药相关的并发症。结论在常规药物治疗的基础上,鞘内注射异烟肼、糖皮质激素、尿激酶和胞二磷胆碱可提高老年中晚期结核性脑膜炎患者的临床疗效。
Objective To investigate the curative effects cerebrospinal fluid replacement and in- trathecal injection of isoniazid, glucocorticoids,urokinase and citicoline on advanced stages of tu- berculous meningitis in elderly patients. Methods Elderly patients treated in the between October 1,2007 and March 31,2012 for advanced stages of 86 case tuberculous meningitis were divided in- to two groups according to whether the intrathecal injection： control group （40 case） and treat- ment group（46 case）. All patients were given conventional drug treatment and cerebrospinal fluid replacement. On this basis,patients in treatment group were additionally given intrathecal injec- tion of isoniazid, glucocorticoids, urokinase and citicoline. Changes in cerebrospinal fluid and clini- cal efficacy were compared between the two groups. Results In treatment group, 32 patients were cured, 10 were improved and 4 underwent ineffective treatment. In control group, 16 patients were cured,8 were improved and 16 underwent ineffective treatment. Compared with control group, clinical efficacy was significantly increased in treatment group （P〈0.05）. No complications were found in both groups. Conclusion Conventional drug treatment combined with intrathecal injec- tion of isoniazid,glucocorticoids, urokinase and citicoline can improve clinical symptoms of tuber- culous meningitis in elderly patients.
出处
《南昌大学学报（医学版）》
CAS
2012年第9期31-34,共4页
Journal of Nanchang University：Medical Sciences
关键词
结核性脑膜炎
鞘内注射
尿激酶
胞二磷胆碱
疗效
cerebrospinal fluid replacement
intrathecal injection
urokinase
citicoline
curative effect
