摘要
目的观察窄谱中波紫外线(NB-UVB)照射联合复方甘草酸苷治疗寻常性银屑病的临床疗效及影响因素。方法 276例寻常性银屑病随机分为两组。治疗组:NB-UVB照射联合复方甘草酸苷口服;对照组:单一口服复方甘草酸苷,疗程均为8周。疗程结束以银屑病皮损面积和严重指数(PASI)评分的降低率评价疗效,并分析临床亚型及分期对疗效的影响。随访3个月,评估复发率。结果治疗组有效率为83.45%,显著高于对照组的54.20%(P<0.01),且点滴型优于斑块型(P<0.01),进行期优于静止期(P<0.01)。复发率治疗组低于对照组(P<0.05)。结论NB-UVB照射联合复方甘草酸苷治疗寻常性银屑病疗效好,不良反应小;其疗效可能与寻常性银屑病亚型、分期有关;达到基本痊愈后逐渐减少NB-UVB照射次数巩固治疗可降低复发率。
Objective To observe the clinical efficacy of Compound Prescription Gancao Suangan combined with narrow-band ultraviolet B （NB-UVB） in the treatment of patients with psoriasis vulgaris. Methods Two hundred and seventy six psoriatic patients were randomly divided into two groups： the treatment group receiving both NB-UVB and Compound Prescription Gancao Suangan, and the control group receiving only Compound Prescription Gancao Suangan. The treatment course all was for 8 weeks. The therapeutic effects on the patients were evaluated. Result The therapeutic effective rates for the treatment and control groups was 83.45% and 54.20%, respectively,the rate of treatment group was significantly higher than that of the control group（P〈0.01）. The efficacy in progress stage was better than in quiescent（P〈0.01）, better response in guttata was showed than that in plaque type（P〈0.01）. However,the relapse rate of treatment group was lower than that of the control group（P〈0.05）. Conclusion The combination therapy of NB-UVB and Compound Prescription Gancao Suangan is safe and effective for psoriasis vulgaris. The effectiveness may also be correlated to the clinical subtype, staging of the disease. After basic cure gradualy reducing radiation times of NB-UVB could lower the relapse rate.
出处
《实用医药杂志》
2012年第10期871-873,共3页
Practical Journal of Medicine & Pharmacy
关键词
银屑病
寻常性
窄谱中波紫外线
复方甘草酸苷
Psoriasis, vulgaris
Narrow band ultraviolet B（NB-UVB）
Compound Prescription Gancao Suangan
