摘要
目的系统性分析复方甘草酸苷联合窄谱中波紫外线(narrow bound ultra violet B light,NB-UVB)治疗银屑病的疗效及安全性。方法检索中国期刊全文数据库、Cochrane图书馆、万方数字化期刊全文数据库及Medline等,收集所有单独常规疗法(口服抗组胺药或/和糖皮质激素)和复方甘草酸苷联合NB-UVB诊治银屑病临床效果的随机对照实验。对文献进行筛选、质量评价和发表偏倚的情况分析,并评价复方甘草酸苷治疗银屑病的疗效与安全性。结果最终入组11篇文献,涉及包括对照组552例患者,实验组584例患者。11个研究均报道了复方甘草酸苷治疗银屑病临床比较的计数结果,采用总有效率(显效率+痊愈率+好转率)为疗效指数进行meta分析。同质性分析发现11个研究之间具有同质性(P=0.60,I^2=0%),因此meta分析采用固定效应模型。Meta分析结果表明,合并OR=0.23(95%CI:0.17~0.31),显著性检验统计量Z=9.57(P<0.05)。9个研究对实验过程中的不良反应进行了报道,同质性分析结果显示其之间同质性(P=0.63,I^2=0%),运用固定效应模型来进行分析。实验组合并OR=2.70(95%CI:1.45~5.02),显著性检验Z=3.14(P<0.05)。结论复方甘草酸苷联合NB-UVB治疗银屑病效果明显,但会有一定程度不良反应的发生。
OBJECTIVE To systematically analyze the efficacy and safety of compound glycyrrhizin combined with narrow bound ultra violet B light(NB-UVB)in the treatment of psoriasis.METHODS Full-text databases of Chinese periodicals,Cochrane Library,Wanfang Digital Periodicals and Medline were searched by computer.All randomized controlled trials(oral antihistamines or/and glucocorticoids)of the clinical efficacy of single routine therapy and compound glycyrrhizin tablets combined with NB-UVB in the treatment of psoriasis were collected.The literature was screened,quality evaluated,and publication biased,and the efficacy and safety of compound glycyrrhizin in the treatment of psoriasis were analyzed.RESULTS Eleven articles were finally grouped.The literature included 552 patients in the control group and 584 patients in the experimental group.Eleven studies reported the results of clinical comparison of compound glycyrrhizin tablets in the treatment of psoriasis.The total effective rate(marked efficiency+cure rate+improvement rate)was used as a meta-analysis index.The homogeneity of 11 studies was tested and found to be homogeneous among 11 studies(P=0.60,I^2=0%).Therefore,meta-analysis of 11 sets of data was performed using a fixed-effect model.The meta-analysis results showed that the combined OR value was 0.23(95%CI:0.17-0.31),and the significance test statistic Z=9.57(P<0.05).Nine studies reported adverse reactions during the experimental process,and homogeneity analysis showed that there was homogeneity between them(P=0.63,I^2=0%).Meta analysis used fixed-effect models for analysis.The OR value of the experimental combination was 2.70(95%CI:1.45-5.02),and the significance test Z=3.14(P<0.05).CONCLUSION Compound glycyrrhizin combined with NB-UVB treatment of psoriasis has obvious effect,but there will be a certain degree of adverse reactions.
作者
胡剑云
梁倩倩
HU Jianyun;LIANG Qianqian(Hangzhou Third Hospital,Hangzhou 310000,China;Hangzhou Huace Ruiou Technology Co.,Ltd.,Hangzhou 310000,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2019年第22期2858-2862,共5页
Chinese Journal of Modern Applied Pharmacy
