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基于分子马达运行机制的骨骼肌生物力学原理研究进展 被引量:2

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摘要 骨骼肌是人体运动之源,一直吸引着国内外学者竞相研究,旨在揭示骨骼肌收缩机理,并且相关研究成果已经获得诺贝尔奖.本文首先阐述了骨骼肌生物力学模型研究现状,归纳出自上而下和自下而上的两种开展骨骼肌生物力学模型的研究策略;并从分子马达的多力场耦合机理与集体运行机制、骨骼肌收缩的生物电化学驱动与控制原理两大方面进行了综述,讨论了进行实验验证的解决方案,总结出基于骨骼肌收缩源头——分子马达的微观运行机制来研究骨骼肌生物力学原理的新思路.最后简要评述了目前研究中存在的不足,探讨了今后需深入研究的方向.
出处 《科学通报》 CAS CSCD 北大核心 2012年第30期2794-2805,共12页 Chinese Science Bulletin
基金 国家自然科学基金(61075101,60643002) 国家重点基础研究发展计划(2011CB013203) 上海交通大学理工交叉研究基金重点项目(LG2011ZD106) 医工交叉研究基金重大项目(YG2010ZD101)资助
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