摘要
目的为更真实地反映药物在血管壁内的分布情况,研究动脉粥样硬化斑块药物扩散系数对血管壁组织中药物扩散的影响。方法采用计算流体动力学方法,考虑5种不同药物扩散系数的斑块,研究血管壁组织和斑块中药物浓度的分布。结果随着斑块药物扩散系数的增加,血管壁中药物含量也逐渐增加,但增加的幅度逐渐趋于平缓。结论当斑块扩散系数小于组织时,斑块对血管壁中药物扩散起抑制作用,反之起促进作用。特别是当斑块中的药物扩散系数远大于血管壁时,其不再影响药物在血管壁中的扩散。在今后的研究中考虑斑块的影响是有必要的,这有利于对药物洗脱支架的优化设计。
Objective To study the effect from drug diffusion coefficient of atherosclerotic plaque on drug diffusion within the arterial wall,so as to truly reflect the drug distributions.Methods Using computational fluid dynamics（CFD） method,five plaque models with different diffusion coefficients were employed to numerically investigate the distributions of drug concentration both within the arterial wall and the plaque.Results The drug concentration in the arterial wall was increased gradually with the diffusion coefficient of the plaque increased;however,the increment would become gentle.Conclusions When the diffusion coefficient in the plaque was smaller than the tissue,the plaque inhibited the drug diffusion within the arterial wall,or conversely,it would promote the diffusion.Especially when the diffusion coefficient in the plaque was much larger than the tissue,it no longer affected the drug diffusion within the arterial wall.It is necessary to consider the impact of plaque in further research,which is beneficial to the optimization design of drug-eluting stents.
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2012年第5期510-514,共5页
Journal of Medical Biomechanics
基金
国家自然科学基金资助项目(10872138)
关键词
动脉粥样硬化斑块
药物洗脱支架
药物扩散
计算流体动力学
Atherosclerotic plaque
Drug-eluting stents（DES）
Drug diffusion
Computational fluid dynamics（CFD）
