摘要
本文用高压液相色谱法(HPLC)分析测定74例肿瘤患者及60例正常人尿中多胺,其结果表明:肿瘤病人尿中腐胺、精眯、精胺及3种多胺总平均值分别为正常人的2.2、4.9、11.2、3.6倍,都有非常明显的统计学差异(P<0.005),特别是肺癌和食管癌更为显著(P<0.001)。证明该方法可用作诊断癌瘤和观察疗效的生化指标。
The urinary polyamine in 74 cancer patients and 60 normal individuals were analysed by HPLC (high-pressure liquid chromatography). The contents of putrescine, spermidine, spermine and total polyamine in the urine of cancer patients were 2.2, 4.9, 11.2 and 3.6 fold higher than those of normal controls respectively (P<0.005). The increased urinary polyamine in patients with lung cancer or esophageal cancer was more significant (P<0.001) than that in other cancer patients. It is suggested that analysis of polyamine might be useful in the diagnosis of cancer and follow-up monitoring of the patients.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1990年第4期211-214,共4页
Chinese Journal of Clinical Oncology
关键词
癌
尿
多胺
精脒
精胺
高效液相色谱
Urinary polyamine
Spermidine
Spermine
High-pressure liquid chromatography (HPLC)
