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绝经相关激素补充治疗的适应证及历史发展 被引量:23

The indications and development history of hormone replacement therapy for menopause
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摘要 在生殖系统之外,雌激素对女性全身多个系统具有广泛的作用。绝经后雌激素缺乏导致围绝经期症状及某些老年慢性疾病风险增加,激素补充治疗(hormone replacement therapy,HRT)的利弊关系不断被修正。目前的证据表明,在"治疗窗口期"启动,并按照规范合理使用HRT,掌握适应证、禁忌证和慎用情况是利大于弊的。现今中国绝经后女性人口众多,但对HRT的知晓率很低,宣传普及绝经知识、探索更加安全的HRT方案将是广大妇产科同道不懈努力的方向。 Estrogen has extensive effects on multiple systems all over the female body, besides reproductive system. Estrogen deficiency in postmenopausal women would cause peri-menopausal symptoms and increase the risks of senile chronic diseases. The risk - benefit balances of hormone replacement therapy (HRT) keep being revised by emerging new evidence. At present, available evidence demonstrates that the benefits of HRT overwhelm its risks if it is initiated in " opportunity window" and administered according to indications, contraindications and cautious conditions. There is a large population of menopausal women in China, but the awareness about HRT is insufficient. So, popularizing the knowledge of menopause, exploring safer protocols of HRT will be the striving directions of Chinese Gynecologists.
作者 郁琦 魏代敏
出处 《中国计划生育和妇产科》 2012年第5期8-12,共5页 Chinese Journal of Family Planning & Gynecotokology
关键词 绝经 激素补充治疗 适应证 menopause hormone replacement therapy indications
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