摘要
胆道闭锁(biliary atresia,BA)是发生于婴儿期的破坏性胆道炎症性疾病,可导致肝内外胆道纤维化闭锁,最终导致肝硬化.胆道闭锁的确切病因和发病机制目前仍不明确,可能的病因包括先天遗传因素、感染因素、炎症、免疫反应、母体因素、血管因素等.BA免疫炎症学说目前得到大多数学者支持,且肝脏病理学改变支持这一学说.本文就近年胆道闭锁发病机制及肝脏病理学的相关研究进展进行综述.
Biliary atresia is an infantile destructive inflammatory cholangiopathy that causes obliteration of both intrahepatic and extrahepatic bile ducts and eventually liver cirrhosis.So far,the exact etiology and pathogenesis of biliary atresia remain unclear,and possible etiologies include congenital and genetic factors,infection,inflammation,immune reaction,maternal factors,and vascular factors.Immunoinflammatory theory has been accepted by most researchers,which is supported by liver pathological changes.This review focuses on the recent progress in understanding pathogenesis and liver pathology in biliary atresia.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第27期2576-2582,共7页
World Chinese Journal of Digestology
关键词
胆道闭锁
发病机制
肝脏病理
病因
免疫反应
Biliary atresia
Pathogenesis
Liver pathology
Etiology
Immune reaction
