摘要
近年来肥胖的发病率显著增加。肥胖与多种慢性肝病相关,尤其与非酒精性脂肪性肝病(NAFLD)高度相关,而NAFLD已成为中国和西方发达国家最常见的肝病。内脏脂肪组织(VAT)对代谢稳态至关重要,其分泌的游离脂肪酸(free fatty acids,FFAs)和脂肪细胞因子在NAFLD的发生中具有重要作用。此外,肥胖是肝硬化患者失代偿及肝细胞肝癌的危险因素之一。在急性肝衰竭时,肥胖意味着预后更差,近来的研究提示肥胖在慢性乙型、丙型病毒性肝炎的进展中亦有作用,肥胖是慢性丙型肝炎抗病毒治疗应答不佳的预测因素之一。
Recently there has been an ever-increasing incidence of obesity,which is associated with a spectrum of chronic liver diseases, particularly non-alcoholic fatty liver disease （NAFLD）. NAFLD has become the most common liver disease in China and industrialized western countries. Visceral adipose tissue （VAT） is essential to the metabolic homeostasis and secretes free fatty acids （FFAs） and adipokines that play a vital role in the development of NAFLD. Furthermore, obesity is an independent one of the risk factors of decompensation in patients with cirrhosis and hepatocellular carcinoma. Obesity may be associated with poor prognosis in patients with acute liver failure. Recent studies suggested that obesity also plays a po- tential role in the progression of chronic hepatitis B and C and that it is a predictor of poor response to the treatment of chronic hepatitis C.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2012年第10期744-747,共4页
Chinese Journal of Practical Internal Medicine
