摘要
Ghrelin能通过生长激素非依赖性机制,刺激食欲、增加体重和诱导肥胖,并参与糖代谢和脂肪代谢,而引起正性能量平衡。Ghrelin通过抑制炎症细胞因子的产生和拮抗心肌重构的作用,以改善心力衰竭恶液质患者的心脏功能,调节能量代谢紊乱。因此,Ghrelin在慢性心力衰竭恶液质患者的能量代谢稳态中,起到重要作用。其逆转和拮抗代谢重构的有益作用,是心力衰竭晚期恶液质治疗的一条新途经。Ghrelin可作为一种监测指标,对病情严重程度和预后进行评估。
Ghrelin stimulates appetite and weight gain,inducing obesity through a growth hormone-independent mechanism.It is involved in glucose and fat metabolism.Ghrelin could improve cardiac function and disturbed energy metabolism through inhibiting the production of inflammatory factors and myocardial remodeling in cachectic patients with chronic heart failure.Therefore,ghrelin plays an important role in maintaining homeostasis of myocardial energy metabolism in cachectic patients with chronic heart failure.With the beneficial effects of ghrelin on reversing myocardial remodeling,it may be a new therapeutic strategy for cachectic patients with end-stage heart failure.As a monitoring index,ghrelin might aid in the evaluation of the severity of the disease and patient prognosis.
出处
《心血管病学进展》
CAS
2011年第2期202-205,共4页
Advances in Cardiovascular Diseases
基金
国家重大基础研究项目973(2006CB503807)
国家自然科学基金(30670847)
