摘要
近年来,从天然产物中寻找高效低毒的先导化合物已成筛选抗HIV药物的重要研究方向。生物碱类化合物作为一类重要的天然产物,数量众多,结构类型复杂,其中有多种抑制和阻断HIV感染的有效成分,通过实验室研究工作和临床用药观察,有望从中获得抗HIV的有效药物。以生物碱类化合物的化学结构为基础,将生物碱类化合物分为异喹啉类、喹啉类、大环类、哌啶类、莨菪烷类、吲哚类、咔唑类、海洋多环胍类、萜类、manzamine型生物碱等10类,对其抗HIV活性进行综述。
In recent years, looking for efficiency and low toxicity of the lead compound from natural products has become the screening of anti-HIV drugs is an important research direction. Natural alkaloids as an important class of natural products has a large number and a complex structure type, which has a variety of suppression and blocking of the active ingredients of HIV infection, it is expected to derive an effective anti-HIV drugs by way of laboratory research work and clinical use. This article is based on the chemical structure of alkaloids, which be divided into 10 classes, such as isoquinoline alkaloid, quinoline alkaloids, macrocyclic alkaloids, piperidine alkaloids, tropane alkaloids, indole alkaloids, carbazole alkaloid, marine polycyclic guanidine alkaloids, terpene alkaloids, manzamine-type alkaloids, briefly reviewed anti-HIV activity of alkaloids compounds.
出处
《现代药物与临床》
CAS
2012年第5期519-522,共4页
Drugs & Clinic
