摘要
目的探讨脂肪细胞因子与2型糖尿病患者下肢血管病变的关系。方法严格选择符合2型糖尿病诊断标准三并排除1型糖尿病、糖尿病酮症酸中毒、肝肾心脏疾病以及其他内分泌疾病的患者100例,分为外周血管病变组(PVD)18例和非外周血管病变组(NPVD)82例。比较两组患者血清IR指数、瘦素、TNF-a、脂联素、空腹血糖、餐后2小时血糖等指标的差异。结果两组2型糖尿病患者血清IR指数、瘦素、TNF-a、脂联素、空腹血糖、餐后2小时血糖在统计学上有明显差异(<0.05),根据简单相关分析(Spear相关分析)和多元逐步回归分析表明脂联素与腰围、IR指数、BP呈明显负相关(<0.05),瘦素与腰围、IR指数,TG呈明显正相关(<0.05),TNF-a与BP、IR指数、瘦素呈明显正相关(<0.05),与脂联素呈明显负相关(<0.05)。结论脂联素、瘦素、TNF-在下肢血管病变发生、发展过程中起着重要的作用,ABI检测无创、客观、有效、费用低廉,对2型糖尿病患者下肢血管病变诊断具有重要意义。
Objective To explore the relationship between adipocytokines and lower extremity vascular disease in patients with type 2 diabetes.Methods 00 cases which were strictly selected according to the type 2 diabetes diagnostic criteria and exclusion of type 1 diabetes,diabetic ketoacidosis,liver and kidney of heart disease and other endocrine diseases were divided into peripheral vascular disease group（18 cases） and non-peripheral vascular disease group（82 cases）.ResultsThe serum IR index,leptin,TNF-a,adiponectin,fasting glucose,2-hour postprandial blood sugar in Two groups of patients with type 2 diabetes were statistically significant difference（P〈0.05）.According to simple correlation analysis（Spear correlation analysis） and multivariate stepwise regression analysis,Adiponectin was negatively correlated with waist circumference,IR index,BP（P〈0.05）,and Leptin was significantly related to waist circumference,IR index,TG（P〈0.05）.while TNF-a was positively correlated with BP,IR index,leptin（P〈0.05）,and Was negatively correlated with adiponectin（P〈0.05）.Conclusions Adiponectin,leptin,TNF-αwere played an important role in the development process of lower extremity vascular disease.The ABI detection is non-invasive,objective,effective and low-cost for type 2 diabetes patients with lower extremity vascular disease,and have important diagnostic significance.
出处
《现代实用医学》
2012年第8期846-848,共3页
Modern Practical Medicine
基金
浙江省中医药科技项目(2006Y054)
浙江省台州市科技计划项目(072RKX04)
浙江省临海市科技计划项目(0732)
