摘要
目的:研究山西省东南部地区女性人群人乳头瘤病毒(HPV)的感染情况、年龄特征及基因型分布,为HPV感染的防治提供理论依据。方法:对1 424例女性患者进行HPV分型检测,并对感染情况及基因亚型分布进行统计学分析。结果:HPV阳性556例,阳性率为39.04%,HPV感染高危型中16型最多,占25.90%。不同年龄组间感染率差异有统计学意义(χ2=33.04,P<0.05),60～岁组感染率最高50.00%。高危型单一感染最多,为473人次,占80.72%。结论:山西省东南部地区HPV感染率处于较高水平,HPV感染率最高的亚型为HPV16,开展HPV基因型的检测对宫颈疾病的防治具有重要意义。
To learn the HPV infection rate, subtype distribution and HPV infection status of women in the southeastern region of shanxi province, so as to provide a scientific basis for the prevention and control of HPV infection. Methods： Cervical tissue specimens from 1424 gynecological clinic patients were examined with Flow through Hybridization and gene chip technique to determine the 21 HPV genotypes. Results： A total of 556 women were positive for HPV detection, the positive rate was 39.04%. Subtype 16 was most among high risk HPV infection, the rate was 25.90%. The difference of rate for different age groups was statistically significant （χ^2 =33.04, P d0.05）. The infective rate of 60 years old was highest （50. 00 % ）. The high risk single infection was most （473 women, 80.72 %）. Conclusioh： Conducting the genotypes detection of HPV has important significance in prevention and treatment of cervical diseases.
出处
《长治医学院学报》
2012年第4期248-250,共3页
Journal of Changzhi Medical College
